Cell type atlas - CBWD5 - The Human Protein Atlas

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CBWD5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CBWD5
Gene descriptionⁱ Full gene name according to HGNC.	COBW domain containing 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at transcript level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	48 NX
Lung	48 NX

B-cells	48 NX
Kidney	49 NX
Colon	48 NX
Liver	43 NX

Basal glandular cells	30 NX
Prostate	30 NX

Basal keratinocytes	58 NX
Skin	58 NX

Bipolar cells	38 NX
Eye	38 NX

Cardiomyocytes	30 NX
Heart muscle	30 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	52 NX
Lung	52 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	65 NX
Eye	65 NX

Cytotrophoblasts	36 NX
Placenta	36 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	18 NX
Pancreas	36 NX
Heart muscle	30 NX
Testis	30 NX
Skin	20 NX
Lung	18 NX
Eye	16 NX
Placenta	12 NX
Prostate	11 NX
Liver	9 NX

Enterocytes	41 NX
Small intestine	65 NX
Colon	34 NX
Rectum	25 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	19 NX
Placenta	19 NX

Fibroblasts	12 NX
Heart muscle	32 NX
Lung	28 NX
Prostate	20 NX
Placenta	12 NX
Skin	11 NX

Glandular cells	17 NX
Prostate	16 NX

Granulocytes	9 NX
Lung	19 NX
Colon	0 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	14 NX
Placenta	14 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	16 NX
Rectum	19 NX
Colon	14 NX

Ito cells	15 NX
Liver	15 NX

Kupffer cells	24 NX
Liver	24 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	20 NX
Testis	20 NX

Macrophages	27 NX
Lung	31 NX
Kidney	30 NX
Skin	26 NX
Testis	26 NX
Pancreas	21 NX
Prostate	8 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	55 NX
Pancreas	55 NX

Mucus-secreting cells	27 NX
Small intestine	34 NX
Colon	33 NX
Rectum	24 NX

Muller glia cells	10 NX
Eye	10 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	46 NX
Colon	60 NX
Small intestine	46 NX
Rectum	32 NX

Peritubular cells	16 NX
Testis	16 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	57 NX
Eye	57 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	25 NX
Heart muscle	31 NX
Pancreas	27 NX
Skin	19 NX
Prostate	10 NX

Spermatocytes	27 NX
Testis	27 NX

Spermatogonia	17 NX
Testis	17 NX

Suprabasal keratinocytes	75 NX
Skin	75 NX

Syncytiotrophoblasts	42 NX
Placenta	42 NX

T-cells	20 NX
Lung	33 NX
Skin	23 NX
Kidney	20 NX
Colon	19 NX
Prostate	18 NX
Liver	18 NX

Undifferentiated cells	28 NX
Small intestine	32 NX
Colon	32 NX
Rectum	26 NX

Urothelial cells	27 NX
Prostate	27 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.