Cell type atlas - NFIB - The Human Protein Atlas

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NFIB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NFIB
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear factor I B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	20

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (AN3-CA, HBEC3-KT, HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	32 NX
Lung	32 NX

B-cells	9 NX
Kidney	22 NX
Liver	8 NX
Colon	3 NX

Basal glandular cells	156 NX
Prostate	156 NX

Basal keratinocytes	239 NX
Skin	239 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	173 NX
Heart muscle	173 NX

Cholangiocytes	204 NX
Liver	204 NX

Ciliated cells	50 NX
Lung	50 NX

Club cells	64 NX
Lung	64 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	4 NX
Placenta	4 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	59 NX
Pancreas	59 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	193 NX
Testis	426 NX
Heart muscle	315 NX
Skin	253 NX
Liver	193 NX
Lung	155 NX
Prostate	143 NX
Placenta	129 NX
Eye	89 NX
Pancreas	54 NX

Enterocytes	45 NX
Small intestine	83 NX
Rectum	54 NX
Colon	22 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	108 NX
Pancreas	108 NX

Extravillous trophoblasts	2 NX
Placenta	2 NX

Fibroblasts	65 NX
Heart muscle	194 NX
Skin	159 NX
Prostate	74 NX
Placenta	45 NX
Lung	37 NX

Glandular cells	158 NX
Prostate	158 NX

Granulocytes	4 NX
Lung	7 NX
Colon	0 NX

Hepatocytes	91 NX
Liver	91 NX

Hofbauer cells	2 NX
Placenta	2 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	22 NX
Rectum	23 NX
Colon	20 NX

Ito cells	177 NX
Liver	177 NX

Kupffer cells	10 NX
Liver	10 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	124 NX
Testis	124 NX

Macrophages	9 NX
Skin	31 NX
Kidney	16 NX
Prostate	11 NX
Lung	6 NX
Testis	4 NX
Pancreas	0 NX

Melanocytes	89 NX
Skin	89 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3 NX
Pancreas	3 NX

Mucus-secreting cells	29 NX
Small intestine	43 NX
Rectum	31 NX
Colon	12 NX

Muller glia cells	261 NX
Eye	261 NX

Pancreatic endocrine cells	67 NX
Pancreas	67 NX

Paneth cells	56 NX
Small intestine	67 NX
Rectum	56 NX
Colon	12 NX

Peritubular cells	46 NX
Testis	46 NX

Proximal tubular cells	159 NX
Kidney	159 NX

Rod photoreceptor cells	9 NX
Eye	9 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	186 NX
Heart muscle	279 NX
Skin	219 NX
Prostate	104 NX
Pancreas	13 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	148 NX
Skin	148 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	2 NX
Skin	23 NX
Kidney	13 NX
Prostate	9 NX
Lung	2 NX
Liver	1 NX
Colon	1 NX

Undifferentiated cells	68 NX
Small intestine	87 NX
Rectum	68 NX
Colon	46 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.