Cell type atlas - OGT - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

OGT

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OGT
Gene descriptionⁱ Full gene name according to HGNC.	O-linked N-acetylglucosamine (GlcNAc) transferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	81 NX
Lung	81 NX

B-cells	39 NX
Liver	54 NX
Colon	25 NX
Kidney	9 NX

Basal glandular cells	32 NX
Prostate	32 NX

Basal keratinocytes	78 NX
Skin	78 NX

Bipolar cells	25 NX
Eye	25 NX

Cardiomyocytes	39 NX
Heart muscle	39 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	20 NX
Lung	20 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	12 NX
Placenta	12 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	12 NX
Pancreas	11 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	43 NX
Prostate	72 NX
Heart muscle	71 NX
Skin	49 NX
Testis	43 NX
Liver	41 NX
Placenta	30 NX
Lung	26 NX
Eye	20 NX
Pancreas	7 NX

Enterocytes	29 NX
Rectum	36 NX
Small intestine	29 NX
Colon	21 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	7 NX
Placenta	7 NX

Fibroblasts	45 NX
Heart muscle	82 NX
Prostate	54 NX
Lung	50 NX
Skin	46 NX
Placenta	17 NX

Glandular cells	43 NX
Prostate	43 NX

Granulocytes	27 NX
Lung	35 NX
Colon	18 NX

Hepatocytes	25 NX
Liver	25 NX

Hofbauer cells	14 NX
Placenta	14 NX

Horizontal cells	38 NX
Eye	38 NX

Intestinal endocrine cells	34 NX
Rectum	47 NX
Colon	20 NX

Ito cells	45 NX
Liver	45 NX

Kupffer cells	65 NX
Liver	65 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	50 NX
Testis	50 NX

Macrophages	36 NX
Skin	52 NX
Testis	39 NX
Lung	36 NX
Prostate	34 NX
Kidney	33 NX
Pancreas	9 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	15 NX
Pancreas	15 NX

Mucus-secreting cells	36 NX
Rectum	44 NX
Small intestine	31 NX
Colon	29 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	15 NX
Pancreas	15 NX

Paneth cells	32 NX
Colon	32 NX
Rectum	32 NX
Small intestine	32 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	12 NX
Kidney	12 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	33 NX
Heart muscle	52 NX
Skin	39 NX
Prostate	33 NX
Pancreas	11 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	74 NX
Skin	74 NX

Syncytiotrophoblasts	9 NX
Placenta	9 NX

T-cells	59 NX
Skin	79 NX
Lung	65 NX
Liver	64 NX
Colon	59 NX
Prostate	57 NX
Kidney	37 NX

Undifferentiated cells	30 NX
Rectum	40 NX
Small intestine	30 NX
Colon	21 NX

Urothelial cells	39 NX
Prostate	39 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.