Cell type atlas - EBP - The Human Protein Atlas

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EBP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EBP
Gene descriptionⁱ Full gene name according to HGNC.	Emopamil binding protein (sterol isomerase)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	42 NX
Liver	88 NX
Colon	43 NX
Kidney	40 NX

Basal glandular cells	45 NX
Prostate	45 NX

Basal keratinocytes	33 NX
Skin	33 NX

Bipolar cells	24 NX
Eye	24 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	82 NX
Liver	82 NX

Ciliated cells	23 NX
Lung	23 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	80 NX
Pancreas	80 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	24 NX
Pancreas	50 NX
Placenta	40 NX
Liver	32 NX
Lung	32 NX
Testis	24 NX
Skin	23 NX
Prostate	19 NX
Heart muscle	18 NX
Eye	16 NX

Enterocytes	136 NX
Small intestine	145 NX
Colon	143 NX
Rectum	98 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	207 NX
Pancreas	207 NX

Extravillous trophoblasts	94 NX
Placenta	94 NX

Fibroblasts	33 NX
Placenta	40 NX
Heart muscle	33 NX
Skin	28 NX
Prostate	12 NX
Lung	6 NX

Glandular cells	42 NX
Prostate	42 NX

Granulocytes	40 NX
Colon	55 NX
Lung	26 NX

Hepatocytes	389 NX
Liver	389 NX

Hofbauer cells	57 NX
Placenta	57 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	29 NX
Rectum	31 NX
Colon	27 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	12 NX
Testis	12 NX

Macrophages	34 NX
Pancreas	94 NX
Prostate	53 NX
Kidney	37 NX
Skin	34 NX
Lung	27 NX
Testis	26 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	48 NX
Pancreas	48 NX

Mucus-secreting cells	72 NX
Colon	117 NX
Small intestine	72 NX
Rectum	63 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	126 NX
Pancreas	126 NX

Paneth cells	130 NX
Colon	147 NX
Small intestine	130 NX
Rectum	95 NX

Peritubular cells	14 NX
Testis	14 NX

Proximal tubular cells	76 NX
Kidney	76 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	21 NX
Pancreas	47 NX
Heart muscle	27 NX
Skin	16 NX
Prostate	15 NX

Spermatocytes	9 NX
Testis	9 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	40 NX
Skin	40 NX

Syncytiotrophoblasts	31 NX
Placenta	31 NX

T-cells	75 NX
Prostate	92 NX
Kidney	86 NX
Colon	75 NX
Skin	69 NX
Liver	64 NX
Lung	30 NX

Undifferentiated cells	134 NX
Colon	166 NX
Small intestine	134 NX
Rectum	118 NX

Urothelial cells	62 NX
Prostate	62 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.