Cell type atlas - NONO - The Human Protein Atlas

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NONO

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NONO
Gene descriptionⁱ Full gene name according to HGNC.	Non-POU domain containing octamer binding
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	72 NX
Lung	72 NX

Alveolar cells type 2	74 NX
Lung	74 NX

B-cells	80 NX
Colon	90 NX
Liver	88 NX
Kidney	67 NX

Basal glandular cells	79 NX
Prostate	79 NX

Basal keratinocytes	112 NX
Skin	112 NX

Bipolar cells	63 NX
Eye	63 NX

Cardiomyocytes	53 NX
Heart muscle	53 NX

Cholangiocytes	94 NX
Liver	94 NX

Ciliated cells	54 NX
Lung	54 NX

Club cells	84 NX
Lung	84 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	105 NX
Placenta	105 NX

Distal tubular cells	48 NX
Kidney	48 NX

Ductal cells	114 NX
Pancreas	114 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	90 NX
Prostate	118 NX
Testis	107 NX
Skin	101 NX
Placenta	93 NX
Pancreas	90 NX
Liver	76 NX
Heart muscle	67 NX
Lung	64 NX
Eye	63 NX

Enterocytes	55 NX
Small intestine	74 NX
Rectum	50 NX
Colon	36 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	97 NX
Pancreas	97 NX

Extravillous trophoblasts	149 NX
Placenta	149 NX

Fibroblasts	89 NX
Lung	143 NX
Skin	100 NX
Prostate	89 NX
Placenta	86 NX
Heart muscle	47 NX

Glandular cells	79 NX
Prostate	79 NX

Granulocytes	85 NX
Lung	105 NX
Colon	64 NX

Hepatocytes	109 NX
Liver	109 NX

Hofbauer cells	99 NX
Placenta	99 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	134 NX
Colon	170 NX
Rectum	98 NX

Ito cells	70 NX
Liver	70 NX

Kupffer cells	136 NX
Liver	136 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	99 NX
Testis	99 NX

Macrophages	84 NX
Skin	91 NX
Pancreas	87 NX
Kidney	84 NX
Testis	83 NX
Prostate	83 NX
Lung	74 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	105 NX
Pancreas	105 NX

Mucus-secreting cells	96 NX
Rectum	109 NX
Small intestine	93 NX
Colon	83 NX

Muller glia cells	78 NX
Eye	78 NX

Pancreatic endocrine cells	111 NX
Pancreas	111 NX

Paneth cells	84 NX
Rectum	87 NX
Small intestine	84 NX
Colon	35 NX

Peritubular cells	120 NX
Testis	120 NX

Proximal tubular cells	94 NX
Kidney	94 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	107 NX
Pancreas	118 NX
Prostate	109 NX
Skin	103 NX
Heart muscle	61 NX

Spermatocytes	23 NX
Testis	23 NX

Spermatogonia	62 NX
Testis	62 NX

Suprabasal keratinocytes	107 NX
Skin	107 NX

Syncytiotrophoblasts	109 NX
Placenta	109 NX

T-cells	85 NX
Colon	98 NX
Skin	96 NX
Liver	88 NX
Kidney	83 NX
Lung	81 NX
Prostate	70 NX

Undifferentiated cells	122 NX
Small intestine	127 NX
Rectum	90 NX
Colon	87 NX

Urothelial cells	84 NX
Prostate	84 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.