Cell type atlas - CCT6A - The Human Protein Atlas

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CCT6A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CCT6A
Gene descriptionⁱ Full gene name according to HGNC.	Chaperonin containing TCP1 subunit 6A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A-431)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	83 NX
Lung	83 NX

Alveolar cells type 2	81 NX
Lung	81 NX

B-cells	77 NX
Liver	110 NX
Colon	82 NX
Kidney	71 NX

Basal glandular cells	149 NX
Prostate	149 NX

Basal keratinocytes	97 NX
Skin	97 NX

Bipolar cells	58 NX
Eye	58 NX

Cardiomyocytes	101 NX
Heart muscle	101 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	237 NX
Lung	237 NX

Club cells	216 NX
Lung	216 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	172 NX
Placenta	172 NX

Distal tubular cells	75 NX
Kidney	75 NX

Ductal cells	213 NX
Pancreas	213 NX

Early spermatids	12 NX
Testis	12 NX

Endothelial cells	113 NX
Pancreas	229 NX
Lung	163 NX
Prostate	160 NX
Testis	137 NX
Placenta	122 NX
Heart muscle	90 NX
Skin	79 NX
Eye	73 NX
Liver	72 NX

Enterocytes	57 NX
Small intestine	58 NX
Colon	52 NX
Rectum	46 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	238 NX
Pancreas	238 NX

Extravillous trophoblasts	208 NX
Placenta	208 NX

Fibroblasts	82 NX
Lung	232 NX
Prostate	101 NX
Placenta	92 NX
Heart muscle	71 NX
Skin	49 NX

Glandular cells	106 NX
Prostate	106 NX

Granulocytes	127 NX
Lung	144 NX
Colon	110 NX

Hepatocytes	62 NX
Liver	62 NX

Hofbauer cells	134 NX
Placenta	134 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	98 NX
Colon	133 NX
Rectum	63 NX

Ito cells	67 NX
Liver	67 NX

Kupffer cells	80 NX
Liver	79 NX

Late spermatids	16 NX
Testis	16 NX

Leydig cells	65 NX
Testis	65 NX

Macrophages	122 NX
Pancreas	147 NX
Prostate	139 NX
Lung	138 NX
Kidney	110 NX
Testis	94 NX
Skin	74 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	225 NX
Pancreas	225 NX

Mucus-secreting cells	84 NX
Colon	103 NX
Rectum	81 NX
Small intestine	67 NX

Muller glia cells	73 NX
Eye	73 NX

Pancreatic endocrine cells	209 NX
Pancreas	209 NX

Paneth cells	74 NX
Rectum	89 NX
Small intestine	74 NX
Colon	20 NX

Peritubular cells	85 NX
Testis	85 NX

Proximal tubular cells	112 NX
Kidney	112 NX

Rod photoreceptor cells	51 NX
Eye	51 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	93 NX
Pancreas	256 NX
Prostate	164 NX
Heart muscle	77 NX
Skin	76 NX

Spermatocytes	81 NX
Testis	81 NX

Spermatogonia	184 NX
Testis	184 NX

Suprabasal keratinocytes	96 NX
Skin	96 NX

Syncytiotrophoblasts	167 NX
Placenta	167 NX

T-cells	87 NX
Lung	125 NX
Prostate	113 NX
Colon	101 NX
Kidney	87 NX
Skin	80 NX
Liver	72 NX

Undifferentiated cells	112 NX
Colon	153 NX
Small intestine	123 NX
Rectum	89 NX

Urothelial cells	124 NX
Prostate	124 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.