Cell type atlas - MDH2 - The Human Protein Atlas

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MDH2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MDH2
Gene descriptionⁱ Full gene name according to HGNC.	Malate dehydrogenase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Citric acid cycle related proteins Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	54 NX
Lung	54 NX

B-cells	114 NX
Liver	141 NX
Kidney	129 NX
Colon	99 NX

Basal glandular cells	145 NX
Prostate	145 NX

Basal keratinocytes	121 NX
Skin	121 NX

Bipolar cells	62 NX
Eye	62 NX

Cardiomyocytes	448 NX
Heart muscle	448 NX

Cholangiocytes	122 NX
Liver	122 NX

Ciliated cells	80 NX
Lung	80 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	110 NX
Kidney	110 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	283 NX
Placenta	283 NX

Distal tubular cells	380 NX
Kidney	380 NX

Ductal cells	210 NX
Pancreas	210 NX

Early spermatids	209 NX
Testis	209 NX

Endothelial cells	86 NX
Pancreas	154 NX
Placenta	126 NX
Heart muscle	107 NX
Eye	100 NX
Skin	87 NX
Prostate	86 NX
Testis	81 NX
Liver	63 NX
Lung	29 NX

Enterocytes	317 NX
Small intestine	387 NX
Colon	205 NX
Rectum	191 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	292 NX
Pancreas	292 NX

Extravillous trophoblasts	258 NX
Placenta	258 NX

Fibroblasts	94 NX
Heart muscle	177 NX
Placenta	169 NX
Prostate	92 NX
Skin	82 NX
Lung	41 NX

Glandular cells	139 NX
Prostate	139 NX

Granulocytes	53 NX
Colon	55 NX
Lung	51 NX

Hepatocytes	241 NX
Liver	241 NX

Hofbauer cells	220 NX
Placenta	220 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	163 NX
Rectum	166 NX
Colon	160 NX

Ito cells	73 NX
Liver	73 NX

Kupffer cells	118 NX
Liver	118 NX

Late spermatids	128 NX
Testis	128 NX

Leydig cells	92 NX
Testis	92 NX

Macrophages	117 NX
Pancreas	239 NX
Kidney	157 NX
Testis	132 NX
Prostate	132 NX
Skin	101 NX
Lung	59 NX

Melanocytes	172 NX
Skin	172 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	171 NX
Pancreas	171 NX

Mucus-secreting cells	227 NX
Colon	330 NX
Rectum	241 NX
Small intestine	175 NX

Muller glia cells	64 NX
Eye	64 NX

Pancreatic endocrine cells	224 NX
Pancreas	224 NX

Paneth cells	228 NX
Rectum	261 NX
Small intestine	228 NX
Colon	196 NX

Peritubular cells	93 NX
Testis	93 NX

Proximal tubular cells	301 NX
Kidney	301 NX

Rod photoreceptor cells	49 NX
Eye	49 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	130 NX
Pancreas	302 NX
Prostate	135 NX
Heart muscle	130 NX
Skin	104 NX

Spermatocytes	72 NX
Testis	72 NX

Spermatogonia	70 NX
Testis	70 NX

Suprabasal keratinocytes	145 NX
Skin	145 NX

Syncytiotrophoblasts	247 NX
Placenta	247 NX

T-cells	109 NX
Kidney	147 NX
Colon	118 NX
Skin	109 NX
Liver	106 NX
Prostate	83 NX
Lung	58 NX

Undifferentiated cells	306 NX
Colon	379 NX
Small intestine	306 NX
Rectum	297 NX

Urothelial cells	194 NX
Prostate	194 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.