Cell type atlas - IGFBP3 - The Human Protein Atlas

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IGFBP3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGFBP3
Gene descriptionⁱ Full gene name according to HGNC.	Insulin like growth factor binding protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts, Urothelial cells, Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (fHDF/TERT166, U-2197, U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts, Urothelial cells, Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	5 NX
Lung	5 NX

B-cells	0 NX
Liver	4 NX
Colon	0 NX
Kidney	0 NX

Basal glandular cells	95 NX
Prostate	95 NX

Basal keratinocytes	407 NX
Skin	407 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	34 NX
Lung	34 NX

Club cells	117 NX
Lung	117 NX

Collecting duct cells	216 NX
Kidney	216 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	46 NX
Placenta	46 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	72 NX
Pancreas	72 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	63 NX
Prostate	265 NX
Heart muscle	178 NX
Lung	102 NX
Liver	74 NX
Skin	54 NX
Testis	52 NX
Placenta	51 NX
Eye	7 NX
Pancreas	0 NX

Enterocytes	0 NX
Small intestine	1 NX
Colon	0 NX
Rectum	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	2 NX
Pancreas	2 NX

Extravillous trophoblasts	1875 NX
Placenta	1875 NX

Fibroblasts	138 NX
Placenta	1269 NX
Heart muscle	190 NX
Lung	79 NX
Prostate	66 NX
Skin	30 NX

Glandular cells	80 NX
Prostate	80 NX

Granulocytes	1 NX
Lung	2 NX
Colon	0 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	73 NX
Placenta	73 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	263 NX
Rectum	391 NX
Colon	136 NX

Ito cells	182 NX
Liver	182 NX

Kupffer cells	8 NX
Liver	8 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	267 NX
Testis	267 NX

Macrophages	3 NX
Skin	20 NX
Lung	5 NX
Prostate	3 NX
Pancreas	2 NX
Testis	2 NX
Kidney	1 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	13 NX
Pancreas	13 NX

Mucus-secreting cells	2 NX
Small intestine	18 NX
Rectum	1 NX
Colon	0 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	20 NX
Pancreas	20 NX

Paneth cells	3 NX
Small intestine	4 NX
Colon	3 NX
Rectum	0 NX

Peritubular cells	6 NX
Testis	6 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	29 NX
Pancreas	538 NX
Heart muscle	101 NX
Prostate	27 NX
Skin	21 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	214 NX
Skin	214 NX

Syncytiotrophoblasts	129 NX
Placenta	129 NX

T-cells	8 NX
Skin	17 NX
Colon	12 NX
Lung	9 NX
Kidney	8 NX
Liver	7 NX
Prostate	0 NX

Undifferentiated cells	1 NX
Small intestine	2 NX
Rectum	0 NX
Colon	0 NX

Urothelial cells	581 NX
Prostate	581 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.