Cell type atlas - NHP2 - The Human Protein Atlas

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NHP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NHP2
Gene descriptionⁱ Full gene name according to HGNC.	NHP2 ribonucleoprotein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	57 NX
Lung	57 NX

B-cells	132 NX
Kidney	156 NX
Liver	154 NX
Colon	108 NX

Basal glandular cells	167 NX
Prostate	167 NX

Basal keratinocytes	172 NX
Skin	172 NX

Bipolar cells	49 NX
Eye	49 NX

Cardiomyocytes	11 NX
Heart muscle	11 NX

Cholangiocytes	120 NX
Liver	120 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	97 NX
Lung	97 NX

Collecting duct cells	120 NX
Kidney	120 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	208 NX
Placenta	208 NX

Distal tubular cells	303 NX
Kidney	303 NX

Ductal cells	170 NX
Pancreas	170 NX

Early spermatids	42 NX
Testis	42 NX

Endothelial cells	112 NX
Placenta	189 NX
Pancreas	183 NX
Prostate	175 NX
Skin	142 NX
Liver	112 NX
Testis	97 NX
Lung	61 NX
Eye	55 NX
Heart muscle	6 NX

Enterocytes	44 NX
Colon	53 NX
Small intestine	44 NX
Rectum	39 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	261 NX
Pancreas	261 NX

Extravillous trophoblasts	296 NX
Placenta	296 NX

Fibroblasts	122 NX
Prostate	142 NX
Lung	135 NX
Placenta	133 NX
Skin	113 NX
Heart muscle	17 NX

Glandular cells	161 NX
Prostate	161 NX

Granulocytes	78 NX
Colon	101 NX
Lung	56 NX

Hepatocytes	143 NX
Liver	143 NX

Hofbauer cells	156 NX
Placenta	156 NX

Horizontal cells	29 NX
Eye	29 NX

Intestinal endocrine cells	122 NX
Rectum	131 NX
Colon	112 NX

Ito cells	77 NX
Liver	77 NX

Kupffer cells	75 NX
Liver	75 NX

Late spermatids	93 NX
Testis	93 NX

Leydig cells	125 NX
Testis	125 NX

Macrophages	98 NX
Kidney	142 NX
Skin	124 NX
Prostate	103 NX
Testis	93 NX
Pancreas	82 NX
Lung	73 NX

Melanocytes	138 NX
Skin	138 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	124 NX
Pancreas	124 NX

Mucus-secreting cells	127 NX
Colon	191 NX
Rectum	127 NX
Small intestine	79 NX

Muller glia cells	47 NX
Eye	47 NX

Pancreatic endocrine cells	191 NX
Pancreas	191 NX

Paneth cells	32 NX
Rectum	136 NX
Small intestine	32 NX
Colon	26 NX

Peritubular cells	92 NX
Testis	92 NX

Proximal tubular cells	216 NX
Kidney	216 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	119 NX
Pancreas	243 NX
Skin	120 NX
Prostate	119 NX
Heart muscle	16 NX

Spermatocytes	92 NX
Testis	92 NX

Spermatogonia	128 NX
Testis	128 NX

Suprabasal keratinocytes	212 NX
Skin	212 NX

Syncytiotrophoblasts	140 NX
Placenta	140 NX

T-cells	91 NX
Kidney	130 NX
Skin	95 NX
Colon	91 NX
Lung	79 NX
Liver	74 NX
Prostate	65 NX

Undifferentiated cells	180 NX
Colon	236 NX
Small intestine	173 NX
Rectum	162 NX

Urothelial cells	243 NX
Prostate	243 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.