Cell type atlas - COMMD10 - The Human Protein Atlas

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COMMD10

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COMMD10
Gene descriptionⁱ Full gene name according to HGNC.	COMM domain containing 10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	18 NX
Lung	18 NX

B-cells	20 NX
Colon	46 NX
Kidney	27 NX
Liver	13 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	16 NX
Eye	16 NX

Cardiomyocytes	38 NX
Heart muscle	38 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	4 NX
Lung	4 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	38 NX
Placenta	38 NX

Distal tubular cells	78 NX
Kidney	78 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	21 NX
Placenta	41 NX
Heart muscle	26 NX
Testis	24 NX
Skin	24 NX
Eye	21 NX
Prostate	20 NX
Liver	16 NX
Pancreas	14 NX
Lung	9 NX

Enterocytes	13 NX
Colon	16 NX
Small intestine	15 NX
Rectum	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	13 NX
Pancreas	13 NX

Extravillous trophoblasts	43 NX
Placenta	43 NX

Fibroblasts	28 NX
Placenta	31 NX
Heart muscle	28 NX
Skin	27 NX
Prostate	18 NX
Lung	13 NX

Glandular cells	28 NX
Prostate	28 NX

Granulocytes	46 NX
Colon	64 NX
Lung	28 NX

Hepatocytes	12 NX
Liver	12 NX

Hofbauer cells	42 NX
Placenta	42 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	10 NX
Colon	14 NX
Rectum	7 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	20 NX
Testis	20 NX

Macrophages	32 NX
Pancreas	47 NX
Skin	39 NX
Kidney	38 NX
Testis	32 NX
Prostate	26 NX
Lung	21 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	16 NX
Pancreas	16 NX

Mucus-secreting cells	22 NX
Colon	24 NX
Rectum	21 NX
Small intestine	18 NX

Muller glia cells	29 NX
Eye	29 NX

Pancreatic endocrine cells	16 NX
Pancreas	16 NX

Paneth cells	14 NX
Rectum	22 NX
Colon	14 NX
Small intestine	11 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	83 NX
Kidney	83 NX

Rod photoreceptor cells	19 NX
Eye	19 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	28 NX
Pancreas	34 NX
Heart muscle	30 NX
Skin	21 NX
Prostate	17 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	17 NX
Testis	17 NX

Suprabasal keratinocytes	22 NX
Skin	22 NX

Syncytiotrophoblasts	41 NX
Placenta	41 NX

T-cells	22 NX
Prostate	48 NX
Kidney	42 NX
Colon	28 NX
Skin	21 NX
Liver	19 NX
Lung	17 NX

Undifferentiated cells	21 NX
Small intestine	24 NX
Colon	21 NX
Rectum	19 NX

Urothelial cells	25 NX
Prostate	25 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.