Cell type atlas - PLK2 - The Human Protein Atlas

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PLK2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLK2
Gene descriptionⁱ Full gene name according to HGNC.	Polo like kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTERT-RPE1, T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	3 NX
Colon	15 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	128 NX
Prostate	128 NX

Basal keratinocytes	126 NX
Skin	126 NX

Bipolar cells	3 NX
Eye	3 NX

Cardiomyocytes	105 NX
Heart muscle	105 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	68 NX
Lung	68 NX

Collecting duct cells	17 NX
Kidney	17 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	56 NX
Placenta	56 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	96 NX
Pancreas	96 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	110 NX
Prostate	320 NX
Placenta	195 NX
Pancreas	158 NX
Heart muscle	136 NX
Lung	102 NX
Skin	89 NX
Testis	76 NX
Liver	74 NX
Eye	73 NX

Enterocytes	37 NX
Colon	61 NX
Small intestine	31 NX
Rectum	22 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	69 NX
Pancreas	69 NX

Extravillous trophoblasts	181 NX
Placenta	181 NX

Fibroblasts	32 NX
Prostate	219 NX
Lung	205 NX
Heart muscle	80 NX
Placenta	29 NX
Skin	25 NX

Glandular cells	45 NX
Prostate	45 NX

Granulocytes	9 NX
Colon	9 NX
Lung	9 NX

Hepatocytes	6 NX
Liver	6 NX

Hofbauer cells	14 NX
Placenta	14 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	81 NX
Colon	99 NX
Rectum	63 NX

Ito cells	52 NX
Liver	52 NX

Kupffer cells	9 NX
Liver	9 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	12 NX
Testis	12 NX

Macrophages	11 NX
Prostate	30 NX
Skin	18 NX
Lung	10 NX
Kidney	5 NX
Testis	4 NX
Pancreas	0 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	25 NX
Colon	58 NX
Small intestine	29 NX
Rectum	17 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	72 NX
Pancreas	72 NX

Paneth cells	41 NX
Colon	55 NX
Rectum	41 NX
Small intestine	25 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	3 NX
Eye	3 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	79 NX
Heart muscle	99 NX
Prostate	79 NX
Skin	73 NX
Pancreas	31 NX

Spermatocytes	72 NX
Testis	72 NX

Spermatogonia	10 NX
Testis	10 NX

Suprabasal keratinocytes	91 NX
Skin	91 NX

Syncytiotrophoblasts	109 NX
Placenta	109 NX

T-cells	6 NX
Prostate	31 NX
Skin	12 NX
Lung	9 NX
Colon	9 NX
Kidney	2 NX
Liver	1 NX

Undifferentiated cells	24 NX
Colon	63 NX
Small intestine	25 NX
Rectum	18 NX

Urothelial cells	54 NX
Prostate	54 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.