Cell type atlas - MARCH6 - The Human Protein Atlas

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MARCH6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MARCH6
Gene descriptionⁱ Full gene name according to HGNC.	Membrane associated ring-CH-type finger 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	67 NX
Colon	93 NX
Liver	64 NX
Kidney	49 NX

Basal glandular cells	0 NX
Prostate	0 NX

Basal keratinocytes	125 NX
Skin	125 NX

Bipolar cells	105 NX
Eye	105 NX

Cardiomyocytes	89 NX
Heart muscle	89 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	63 NX
Lung	63 NX

Club cells	57 NX
Lung	57 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	47 NX
Placenta	47 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	0 NX
Pancreas	0 NX

Early spermatids	9 NX
Testis	9 NX

Endothelial cells	59 NX
Skin	99 NX
Heart muscle	91 NX
Liver	88 NX
Testis	59 NX
Eye	53 NX
Placenta	46 NX
Lung	41 NX
Prostate	0 NX
Pancreas	0 NX

Enterocytes	67 NX
Small intestine	103 NX
Rectum	94 NX
Colon	51 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	0 NX
Pancreas	0 NX

Extravillous trophoblasts	24 NX
Placenta	24 NX

Fibroblasts	55 NX
Skin	100 NX
Heart muscle	80 NX
Lung	55 NX
Placenta	43 NX
Prostate	0 NX

Glandular cells	0 NX
Prostate	0 NX

Granulocytes	49 NX
Lung	51 NX
Colon	46 NX

Hepatocytes	72 NX
Liver	72 NX

Hofbauer cells	33 NX
Placenta	32 NX

Horizontal cells	129 NX
Eye	129 NX

Intestinal endocrine cells	96 NX
Rectum	96 NX
Colon	95 NX

Ito cells	59 NX
Liver	59 NX

Kupffer cells	55 NX
Liver	55 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	65 NX
Testis	65 NX

Macrophages	39 NX
Skin	71 NX
Kidney	40 NX
Testis	38 NX
Lung	37 NX
Pancreas	0 NX
Prostate	0 NX

Melanocytes	89 NX
Skin	89 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	74 NX
Rectum	75 NX
Small intestine	71 NX
Colon	47 NX

Muller glia cells	53 NX
Eye	53 NX

Pancreatic endocrine cells	0 NX
Pancreas	0 NX

Paneth cells	56 NX
Rectum	64 NX
Small intestine	56 NX
Colon	35 NX

Peritubular cells	72 NX
Testis	72 NX

Proximal tubular cells	53 NX
Kidney	53 NX

Rod photoreceptor cells	79 NX
Eye	79 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	80 NX
Skin	104 NX
Heart muscle	97 NX
Prostate	0 NX
Pancreas	0 NX

Spermatocytes	84 NX
Testis	84 NX

Spermatogonia	67 NX
Testis	67 NX

Suprabasal keratinocytes	119 NX
Skin	119 NX

Syncytiotrophoblasts	68 NX
Placenta	68 NX

T-cells	58 NX
Skin	86 NX
Colon	66 NX
Kidney	58 NX
Lung	55 NX
Liver	55 NX
Prostate	0 NX

Undifferentiated cells	58 NX
Rectum	71 NX
Small intestine	54 NX
Colon	46 NX

Urothelial cells	0 NX
Prostate	0 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.