Cell type atlas - CBR4 - The Human Protein Atlas

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CBR4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CBR4
Gene descriptionⁱ Full gene name according to HGNC.	Carbonyl reductase 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	7 NX
Lung	7 NX

B-cells	22 NX
Kidney	49 NX
Liver	22 NX
Colon	12 NX

Basal glandular cells	29 NX
Prostate	29 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	35 NX
Placenta	35 NX

Distal tubular cells	43 NX
Kidney	43 NX

Ductal cells	52 NX
Pancreas	52 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	15 NX
Testis	34 NX
Pancreas	32 NX
Placenta	24 NX
Skin	23 NX
Prostate	15 NX
Eye	15 NX
Liver	14 NX
Heart muscle	12 NX
Lung	9 NX

Enterocytes	26 NX
Small intestine	27 NX
Rectum	25 NX
Colon	14 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	22 NX
Placenta	22 NX

Fibroblasts	18 NX
Heart muscle	31 NX
Placenta	21 NX
Skin	16 NX
Prostate	9 NX
Lung	4 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	59 NX
Eye	59 NX

Intestinal endocrine cells	28 NX
Colon	31 NX
Rectum	26 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	19 NX
Testis	19 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	19 NX
Testis	30 NX
Pancreas	23 NX
Kidney	20 NX
Prostate	20 NX
Lung	13 NX
Skin	12 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	22 NX
Pancreas	22 NX

Mucus-secreting cells	21 NX
Small intestine	38 NX
Rectum	21 NX
Colon	16 NX

Muller glia cells	38 NX
Eye	38 NX

Pancreatic endocrine cells	34 NX
Pancreas	34 NX

Paneth cells	29 NX
Small intestine	67 NX
Rectum	29 NX
Colon	14 NX

Peritubular cells	29 NX
Testis	29 NX

Proximal tubular cells	68 NX
Kidney	68 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	15 NX
Skin	19 NX
Prostate	16 NX
Heart muscle	15 NX
Pancreas	14 NX

Spermatocytes	50 NX
Testis	50 NX

Spermatogonia	34 NX
Testis	34 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	17 NX
Placenta	17 NX

T-cells	26 NX
Liver	39 NX
Prostate	26 NX
Kidney	20 NX
Colon	16 NX
Skin	11 NX
Lung	4 NX

Undifferentiated cells	23 NX
Small intestine	33 NX
Rectum	22 NX
Colon	20 NX

Urothelial cells	19 NX
Prostate	19 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.