Cell type atlas - RAB5A - The Human Protein Atlas

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RAB5A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RAB5A
Gene descriptionⁱ Full gene name according to HGNC.	RAB5A, member RAS oncogene family
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	37 NX
Colon	48 NX
Liver	32 NX
Kidney	31 NX

Basal glandular cells	109 NX
Prostate	109 NX

Basal keratinocytes	151 NX
Skin	151 NX

Bipolar cells	33 NX
Eye	33 NX

Cardiomyocytes	53 NX
Heart muscle	53 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	67 NX
Placenta	67 NX

Distal tubular cells	88 NX
Kidney	88 NX

Ductal cells	49 NX
Pancreas	49 NX

Early spermatids	15 NX
Testis	15 NX

Endothelial cells	61 NX
Prostate	121 NX
Skin	107 NX
Placenta	66 NX
Lung	64 NX
Pancreas	61 NX
Testis	54 NX
Heart muscle	53 NX
Eye	45 NX
Liver	36 NX

Enterocytes	53 NX
Colon	68 NX
Rectum	60 NX
Small intestine	43 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	40 NX
Pancreas	40 NX

Extravillous trophoblasts	57 NX
Placenta	57 NX

Fibroblasts	76 NX
Prostate	104 NX
Skin	81 NX
Lung	74 NX
Placenta	56 NX
Heart muscle	53 NX

Glandular cells	98 NX
Prostate	98 NX

Granulocytes	84 NX
Colon	110 NX
Lung	58 NX

Hepatocytes	36 NX
Liver	36 NX

Hofbauer cells	48 NX
Placenta	48 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	59 NX
Colon	88 NX
Rectum	31 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	43 NX
Liver	43 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	56 NX
Skin	111 NX
Prostate	73 NX
Lung	54 NX
Pancreas	52 NX
Testis	50 NX
Kidney	38 NX

Melanocytes	79 NX
Skin	79 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	42 NX
Pancreas	42 NX

Mucus-secreting cells	43 NX
Colon	75 NX
Rectum	43 NX
Small intestine	37 NX

Muller glia cells	65 NX
Eye	65 NX

Pancreatic endocrine cells	49 NX
Pancreas	49 NX

Paneth cells	39 NX
Colon	75 NX
Small intestine	39 NX
Rectum	37 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	49 NX
Kidney	49 NX

Rod photoreceptor cells	31 NX
Eye	31 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	76 NX
Prostate	102 NX
Skin	95 NX
Heart muscle	55 NX
Pancreas	48 NX

Spermatocytes	20 NX
Testis	20 NX

Spermatogonia	26 NX
Testis	26 NX

Suprabasal keratinocytes	164 NX
Skin	164 NX

Syncytiotrophoblasts	137 NX
Placenta	137 NX

T-cells	45 NX
Skin	117 NX
Prostate	65 NX
Colon	58 NX
Kidney	42 NX
Liver	36 NX
Lung	32 NX

Undifferentiated cells	37 NX
Colon	49 NX
Rectum	36 NX
Small intestine	28 NX

Urothelial cells	132 NX
Prostate	132 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.