Cell type atlas - EML4 - The Human Protein Atlas

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EML4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EML4
Gene descriptionⁱ Full gene name according to HGNC.	Echinoderm microtubule associated protein like 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Hep G2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	103 NX
Lung	103 NX

B-cells	87 NX
Colon	160 NX
Liver	74 NX
Kidney	62 NX

Basal glandular cells	60 NX
Prostate	60 NX

Basal keratinocytes	60 NX
Skin	60 NX

Bipolar cells	36 NX
Eye	36 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	69 NX
Lung	69 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	45 NX
Eye	45 NX

Cytotrophoblasts	112 NX
Placenta	112 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	25 NX
Testis	25 NX

Endothelial cells	35 NX
Prostate	84 NX
Skin	63 NX
Placenta	45 NX
Lung	35 NX
Eye	35 NX
Heart muscle	30 NX
Pancreas	29 NX
Liver	27 NX
Testis	21 NX

Enterocytes	47 NX
Colon	61 NX
Small intestine	46 NX
Rectum	41 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	65 NX
Pancreas	65 NX

Extravillous trophoblasts	37 NX
Placenta	37 NX

Fibroblasts	72 NX
Placenta	152 NX
Skin	67 NX
Prostate	47 NX
Lung	47 NX
Heart muscle	20 NX

Glandular cells	58 NX
Prostate	58 NX

Granulocytes	46 NX
Lung	56 NX
Colon	37 NX

Hepatocytes	55 NX
Liver	55 NX

Hofbauer cells	62 NX
Placenta	62 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	98 NX
Colon	112 NX
Rectum	84 NX

Ito cells	49 NX
Liver	49 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	23 NX
Testis	23 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	58 NX
Lung	179 NX
Pancreas	145 NX
Kidney	62 NX
Skin	40 NX
Prostate	38 NX
Testis	30 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	24 NX
Pancreas	24 NX

Mucus-secreting cells	57 NX
Small intestine	81 NX
Colon	53 NX
Rectum	50 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	58 NX
Small intestine	77 NX
Rectum	58 NX
Colon	26 NX

Peritubular cells	22 NX
Testis	22 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	48 NX
Eye	48 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	46 NX
Heart muscle	59 NX
Skin	54 NX
Prostate	44 NX
Pancreas	20 NX

Spermatocytes	40 NX
Testis	40 NX

Spermatogonia	39 NX
Testis	39 NX

Suprabasal keratinocytes	70 NX
Skin	70 NX

Syncytiotrophoblasts	99 NX
Placenta	99 NX

T-cells	96 NX
Skin	467 NX
Colon	235 NX
Lung	201 NX
Kidney	96 NX
Prostate	52 NX
Liver	44 NX

Undifferentiated cells	61 NX
Small intestine	93 NX
Colon	61 NX
Rectum	57 NX

Urothelial cells	86 NX
Prostate	86 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.