Cell type atlas - PDIA6 - The Human Protein Atlas

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PDIA6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDIA6
Gene descriptionⁱ Full gene name according to HGNC.	Protein disulfide isomerase family A member 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	95 NX
Lung	95 NX

B-cells	112 NX
Liver	410 NX
Colon	125 NX
Kidney	89 NX

Basal glandular cells	206 NX
Prostate	206 NX

Basal keratinocytes	92 NX
Skin	92 NX

Bipolar cells	66 NX
Eye	66 NX

Cardiomyocytes	27 NX
Heart muscle	27 NX

Cholangiocytes	153 NX
Liver	153 NX

Ciliated cells	108 NX
Lung	108 NX

Club cells	162 NX
Lung	162 NX

Collecting duct cells	187 NX
Kidney	187 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	420 NX
Placenta	420 NX

Distal tubular cells	37 NX
Kidney	37 NX

Ductal cells	264 NX
Pancreas	264 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	114 NX
Placenta	319 NX
Prostate	229 NX
Pancreas	226 NX
Skin	135 NX
Lung	117 NX
Eye	111 NX
Liver	110 NX
Testis	109 NX
Heart muscle	41 NX

Enterocytes	100 NX
Rectum	106 NX
Colon	106 NX
Small intestine	98 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	211 NX
Pancreas	211 NX

Extravillous trophoblasts	955 NX
Placenta	955 NX

Fibroblasts	174 NX
Placenta	304 NX
Prostate	289 NX
Lung	174 NX
Skin	151 NX
Heart muscle	75 NX

Glandular cells	256 NX
Prostate	256 NX

Granulocytes	129 NX
Colon	156 NX
Lung	102 NX

Hepatocytes	285 NX
Liver	285 NX

Hofbauer cells	370 NX
Placenta	370 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	151 NX
Colon	190 NX
Rectum	112 NX

Ito cells	245 NX
Liver	245 NX

Kupffer cells	138 NX
Liver	138 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	112 NX
Testis	112 NX

Macrophages	137 NX
Prostate	217 NX
Pancreas	206 NX
Kidney	138 NX
Skin	128 NX
Testis	123 NX
Lung	111 NX

Melanocytes	189 NX
Skin	189 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	126 NX
Pancreas	126 NX

Mucus-secreting cells	149 NX
Colon	450 NX
Rectum	136 NX
Small intestine	113 NX

Muller glia cells	95 NX
Eye	95 NX

Pancreatic endocrine cells	191 NX
Pancreas	191 NX

Paneth cells	101 NX
Rectum	170 NX
Colon	101 NX
Small intestine	84 NX

Peritubular cells	127 NX
Testis	127 NX

Proximal tubular cells	98 NX
Kidney	98 NX

Rod photoreceptor cells	46 NX
Eye	46 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	115 NX
Pancreas	480 NX
Prostate	134 NX
Skin	102 NX
Heart muscle	42 NX

Spermatocytes	96 NX
Testis	96 NX

Spermatogonia	140 NX
Testis	140 NX

Suprabasal keratinocytes	90 NX
Skin	90 NX

Syncytiotrophoblasts	463 NX
Placenta	463 NX

T-cells	112 NX
Prostate	205 NX
Colon	131 NX
Kidney	118 NX
Skin	112 NX
Liver	103 NX
Lung	96 NX

Undifferentiated cells	196 NX
Colon	326 NX
Small intestine	208 NX
Rectum	158 NX

Urothelial cells	241 NX
Prostate	241 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.