Cell type atlas - LBR - The Human Protein Atlas

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LBR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LBR
Gene descriptionⁱ Full gene name according to HGNC.	Lamin B receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	74 NX
Kidney	85 NX
Liver	74 NX
Colon	57 NX

Basal glandular cells	22 NX
Prostate	22 NX

Basal keratinocytes	24 NX
Skin	24 NX

Bipolar cells	4 NX
Eye	4 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	28 NX
Lung	28 NX

Club cells	46 NX
Lung	46 NX

Collecting duct cells	30 NX
Kidney	30 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	43 NX
Heart muscle	100 NX
Pancreas	61 NX
Placenta	51 NX
Prostate	48 NX
Liver	43 NX
Skin	31 NX
Eye	29 NX
Lung	26 NX
Testis	16 NX

Enterocytes	17 NX
Rectum	30 NX
Small intestine	18 NX
Colon	17 NX

Erythroid cells	164 NX
Liver	164 NX

Exocrine glandular cells	17 NX
Pancreas	17 NX

Extravillous trophoblasts	19 NX
Placenta	19 NX

Fibroblasts	26 NX
Placenta	28 NX
Lung	27 NX
Prostate	26 NX
Skin	26 NX
Heart muscle	21 NX

Glandular cells	27 NX
Prostate	27 NX

Granulocytes	9 NX
Lung	19 NX
Colon	0 NX

Hepatocytes	64 NX
Liver	64 NX

Hofbauer cells	38 NX
Placenta	38 NX

Horizontal cells	11 NX
Eye	11 NX

Intestinal endocrine cells	26 NX
Rectum	28 NX
Colon	24 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	84 NX
Liver	84 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	51 NX
Kidney	75 NX
Pancreas	70 NX
Testis	56 NX
Lung	46 NX
Prostate	46 NX
Skin	14 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	15 NX
Pancreas	15 NX

Mucus-secreting cells	31 NX
Small intestine	42 NX
Rectum	33 NX
Colon	29 NX

Muller glia cells	12 NX
Eye	12 NX

Pancreatic endocrine cells	18 NX
Pancreas	18 NX

Paneth cells	21 NX
Rectum	38 NX
Small intestine	21 NX
Colon	9 NX

Peritubular cells	30 NX
Testis	30 NX

Proximal tubular cells	23 NX
Kidney	23 NX

Rod photoreceptor cells	10 NX
Eye	10 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	33 NX
Heart muscle	92 NX
Prostate	35 NX
Skin	31 NX
Pancreas	15 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	9 NX
Placenta	9 NX

T-cells	46 NX
Kidney	99 NX
Lung	88 NX
Liver	51 NX
Colon	46 NX
Prostate	31 NX
Skin	29 NX

Undifferentiated cells	63 NX
Colon	66 NX
Rectum	63 NX
Small intestine	49 NX

Urothelial cells	29 NX
Prostate	29 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.