Cell type atlas - DEGS1 - The Human Protein Atlas

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DEGS1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DEGS1
Gene descriptionⁱ Full gene name according to HGNC.	Delta 4-desaturase, sphingolipid 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Cytotrophoblasts, Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Cytotrophoblasts, Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	28 NX
Lung	28 NX

B-cells	38 NX
Kidney	120 NX
Colon	61 NX
Liver	7 NX

Basal glandular cells	38 NX
Prostate	38 NX

Basal keratinocytes	219 NX
Skin	219 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	16 NX
Heart muscle	16 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	23 NX
Lung	23 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	10 NX
Kidney	10 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	230 NX
Placenta	230 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	15 NX
Testis	15 NX

Endothelial cells	50 NX
Placenta	163 NX
Pancreas	79 NX
Liver	72 NX
Prostate	62 NX
Skin	52 NX
Eye	50 NX
Lung	44 NX
Testis	34 NX
Heart muscle	20 NX

Enterocytes	4 NX
Small intestine	17 NX
Rectum	4 NX
Colon	2 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	39 NX
Pancreas	39 NX

Extravillous trophoblasts	37 NX
Placenta	37 NX

Fibroblasts	84 NX
Placenta	142 NX
Prostate	134 NX
Skin	74 NX
Lung	45 NX
Heart muscle	17 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	104 NX
Colon	110 NX
Lung	98 NX

Hepatocytes	18 NX
Liver	18 NX

Hofbauer cells	86 NX
Placenta	86 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	14 NX
Colon	17 NX
Rectum	12 NX

Ito cells	60 NX
Liver	60 NX

Kupffer cells	49 NX
Liver	49 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	58 NX
Testis	58 NX

Macrophages	80 NX
Pancreas	152 NX
Testis	95 NX
Skin	88 NX
Prostate	81 NX
Kidney	62 NX
Lung	52 NX

Melanocytes	66 NX
Skin	66 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	76 NX
Pancreas	76 NX

Mucus-secreting cells	5 NX
Small intestine	7 NX
Colon	5 NX
Rectum	5 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	6 NX
Small intestine	7 NX
Colon	6 NX
Rectum	3 NX

Peritubular cells	75 NX
Testis	75 NX

Proximal tubular cells	26 NX
Kidney	26 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	104 NX
Testis	104 NX

Smooth muscle cells	86 NX
Pancreas	182 NX
Prostate	86 NX
Skin	84 NX
Heart muscle	27 NX

Spermatocytes	67 NX
Testis	67 NX

Spermatogonia	43 NX
Testis	43 NX

Suprabasal keratinocytes	280 NX
Skin	280 NX

Syncytiotrophoblasts	166 NX
Placenta	166 NX

T-cells	61 NX
Skin	70 NX
Colon	70 NX
Prostate	61 NX
Kidney	61 NX
Liver	44 NX
Lung	26 NX

Undifferentiated cells	6 NX
Rectum	6 NX
Small intestine	5 NX
Colon	5 NX

Urothelial cells	13 NX
Prostate	13 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.