Cell type atlas - ADAM15 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ADAM15

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADAM15
Gene descriptionⁱ Full gene name according to HGNC.	ADAM metallopeptidase domain 15
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Extravillous trophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (myeloid DC, classical monocyte, intermediate monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (PC-3, RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Extravillous trophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	7 NX
Lung	7 NX

B-cells	6 NX
Liver	7 NX
Colon	7 NX
Kidney	5 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	44 NX
Skin	44 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	9 NX
Heart muscle	9 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	4 NX
Lung	4 NX

Club cells	6 NX
Lung	6 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	9 NX
Placenta	9 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	34 NX
Pancreas	34 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	87 NX
Placenta	192 NX
Liver	133 NX
Testis	132 NX
Prostate	93 NX
Heart muscle	83 NX
Skin	62 NX
Pancreas	32 NX
Eye	29 NX
Lung	6 NX

Enterocytes	58 NX
Colon	140 NX
Rectum	53 NX
Small intestine	40 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	22 NX
Pancreas	22 NX

Extravillous trophoblasts	139 NX
Placenta	139 NX

Fibroblasts	17 NX
Skin	33 NX
Prostate	17 NX
Placenta	16 NX
Heart muscle	8 NX
Lung	7 NX

Glandular cells	43 NX
Prostate	43 NX

Granulocytes	1 NX
Lung	2 NX
Colon	0 NX

Hepatocytes	17 NX
Liver	17 NX

Hofbauer cells	29 NX
Placenta	29 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	12 NX
Rectum	21 NX
Colon	3 NX

Ito cells	51 NX
Liver	51 NX

Kupffer cells	57 NX
Liver	57 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	16 NX
Testis	16 NX

Macrophages	19 NX
Skin	39 NX
Kidney	26 NX
Testis	21 NX
Prostate	17 NX
Pancreas	14 NX
Lung	5 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	4 NX
Pancreas	4 NX

Mucus-secreting cells	62 NX
Colon	107 NX
Rectum	54 NX
Small intestine	54 NX

Muller glia cells	8 NX
Eye	8 NX

Pancreatic endocrine cells	31 NX
Pancreas	31 NX

Paneth cells	52 NX
Rectum	61 NX
Colon	52 NX
Small intestine	25 NX

Peritubular cells	17 NX
Testis	17 NX

Proximal tubular cells	2 NX
Kidney	2 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	16 NX
Skin	21 NX
Pancreas	16 NX
Prostate	14 NX
Heart muscle	9 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	50 NX
Skin	50 NX

Syncytiotrophoblasts	15 NX
Placenta	15 NX

T-cells	5 NX
Skin	20 NX
Kidney	10 NX
Colon	9 NX
Prostate	4 NX
Liver	3 NX
Lung	0 NX

Undifferentiated cells	54 NX
Colon	90 NX
Rectum	54 NX
Small intestine	33 NX

Urothelial cells	32 NX
Prostate	32 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.