Cell type atlas - HDGF - The Human Protein Atlas

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HDGF

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HDGF
Gene descriptionⁱ Full gene name according to HGNC.	Heparin binding growth factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	86 NX
Lung	86 NX

B-cells	37 NX
Kidney	40 NX
Liver	35 NX
Colon	33 NX

Basal glandular cells	146 NX
Prostate	146 NX

Basal keratinocytes	131 NX
Skin	131 NX

Bipolar cells	61 NX
Eye	61 NX

Cardiomyocytes	82 NX
Heart muscle	82 NX

Cholangiocytes	79 NX
Liver	79 NX

Ciliated cells	123 NX
Lung	123 NX

Club cells	81 NX
Lung	81 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	39 NX
Placenta	39 NX

Distal tubular cells	68 NX
Kidney	68 NX

Ductal cells	90 NX
Pancreas	90 NX

Early spermatids	38 NX
Testis	38 NX

Endothelial cells	47 NX
Prostate	169 NX
Skin	84 NX
Lung	55 NX
Testis	47 NX
Liver	47 NX
Pancreas	43 NX
Heart muscle	40 NX
Placenta	39 NX
Eye	37 NX

Enterocytes	110 NX
Small intestine	125 NX
Colon	110 NX
Rectum	90 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	112 NX
Pancreas	112 NX

Extravillous trophoblasts	91 NX
Placenta	91 NX

Fibroblasts	73 NX
Prostate	139 NX
Lung	90 NX
Skin	79 NX
Placenta	33 NX
Heart muscle	31 NX

Glandular cells	173 NX
Prostate	173 NX

Granulocytes	30 NX
Colon	37 NX
Lung	23 NX

Hepatocytes	144 NX
Liver	144 NX

Hofbauer cells	46 NX
Placenta	46 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	120 NX
Colon	122 NX
Rectum	117 NX

Ito cells	28 NX
Liver	28 NX

Kupffer cells	33 NX
Liver	33 NX

Late spermatids	33 NX
Testis	33 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	56 NX
Prostate	77 NX
Kidney	71 NX
Skin	59 NX
Lung	56 NX
Pancreas	30 NX
Testis	28 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	38 NX
Pancreas	38 NX

Mucus-secreting cells	83 NX
Colon	101 NX
Small intestine	93 NX
Rectum	81 NX

Muller glia cells	56 NX
Eye	56 NX

Pancreatic endocrine cells	134 NX
Pancreas	134 NX

Paneth cells	52 NX
Rectum	64 NX
Colon	52 NX
Small intestine	46 NX

Peritubular cells	43 NX
Testis	43 NX

Proximal tubular cells	94 NX
Kidney	94 NX

Rod photoreceptor cells	31 NX
Eye	31 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	49 NX
Prostate	97 NX
Skin	52 NX
Pancreas	49 NX
Heart muscle	26 NX

Spermatocytes	29 NX
Testis	29 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	139 NX
Skin	139 NX

Syncytiotrophoblasts	46 NX
Placenta	46 NX

T-cells	42 NX
Prostate	61 NX
Skin	60 NX
Kidney	47 NX
Colon	42 NX
Lung	36 NX
Liver	25 NX

Undifferentiated cells	82 NX
Colon	106 NX
Small intestine	105 NX
Rectum	80 NX

Urothelial cells	207 NX
Prostate	207 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.