Cell type atlas - SDHC - The Human Protein Atlas

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SDHC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SDHC
Gene descriptionⁱ Full gene name according to HGNC.	Succinate dehydrogenase complex subunit C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Citric acid cycle related proteins Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	85 NX
Kidney	98 NX
Liver	74 NX
Colon	72 NX

Basal glandular cells	121 NX
Prostate	121 NX

Basal keratinocytes	55 NX
Skin	55 NX

Bipolar cells	71 NX
Eye	71 NX

Cardiomyocytes	88 NX
Heart muscle	88 NX

Cholangiocytes	163 NX
Liver	163 NX

Ciliated cells	98 NX
Lung	98 NX

Club cells	59 NX
Lung	59 NX

Collecting duct cells	143 NX
Kidney	143 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	208 NX
Placenta	208 NX

Distal tubular cells	658 NX
Kidney	658 NX

Ductal cells	185 NX
Pancreas	185 NX

Early spermatids	14 NX
Testis	14 NX

Endothelial cells	65 NX
Pancreas	201 NX
Placenta	124 NX
Testis	87 NX
Prostate	72 NX
Skin	69 NX
Eye	62 NX
Liver	56 NX
Lung	38 NX
Heart muscle	30 NX

Enterocytes	107 NX
Small intestine	132 NX
Rectum	106 NX
Colon	71 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	128 NX
Pancreas	128 NX

Extravillous trophoblasts	211 NX
Placenta	211 NX

Fibroblasts	63 NX
Placenta	133 NX
Lung	63 NX
Skin	62 NX
Prostate	62 NX
Heart muscle	49 NX

Glandular cells	95 NX
Prostate	95 NX

Granulocytes	57 NX
Lung	58 NX
Colon	55 NX

Hepatocytes	207 NX
Liver	207 NX

Hofbauer cells	209 NX
Placenta	209 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	64 NX
Rectum	84 NX
Colon	44 NX

Ito cells	76 NX
Liver	76 NX

Kupffer cells	102 NX
Liver	102 NX

Late spermatids	26 NX
Testis	26 NX

Leydig cells	95 NX
Testis	95 NX

Macrophages	84 NX
Pancreas	220 NX
Kidney	142 NX
Testis	96 NX
Prostate	96 NX
Lung	68 NX
Skin	66 NX

Melanocytes	123 NX
Skin	123 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	206 NX
Pancreas	206 NX

Mucus-secreting cells	96 NX
Rectum	103 NX
Colon	95 NX
Small intestine	75 NX

Muller glia cells	90 NX
Eye	90 NX

Pancreatic endocrine cells	123 NX
Pancreas	123 NX

Paneth cells	105 NX
Rectum	120 NX
Small intestine	105 NX
Colon	20 NX

Peritubular cells	103 NX
Testis	103 NX

Proximal tubular cells	706 NX
Kidney	706 NX

Rod photoreceptor cells	62 NX
Eye	62 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	92 NX
Pancreas	176 NX
Prostate	92 NX
Skin	81 NX
Heart muscle	59 NX

Spermatocytes	90 NX
Testis	90 NX

Spermatogonia	105 NX
Testis	105 NX

Suprabasal keratinocytes	67 NX
Skin	67 NX

Syncytiotrophoblasts	257 NX
Placenta	257 NX

T-cells	81 NX
Kidney	151 NX
Liver	88 NX
Colon	81 NX
Prostate	65 NX
Skin	63 NX
Lung	39 NX

Undifferentiated cells	140 NX
Colon	147 NX
Small intestine	143 NX
Rectum	133 NX

Urothelial cells	130 NX
Prostate	130 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.