Cell type atlas - BCL10 - The Human Protein Atlas

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BCL10

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BCL10
Gene descriptionⁱ Full gene name according to HGNC.	B cell CLL/lymphoma 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HUVEC TERT2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	32 NX
Colon	67 NX
Liver	28 NX
Kidney	22 NX

Basal glandular cells	122 NX
Prostate	122 NX

Basal keratinocytes	172 NX
Skin	172 NX

Bipolar cells	5 NX
Eye	5 NX

Cardiomyocytes	4 NX
Heart muscle	4 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	13 NX
Placenta	13 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	59 NX
Pancreas	59 NX

Early spermatids	42 NX
Testis	42 NX

Endothelial cells	34 NX
Prostate	67 NX
Skin	64 NX
Pancreas	61 NX
Lung	55 NX
Placenta	34 NX
Testis	26 NX
Liver	22 NX
Heart muscle	18 NX
Eye	16 NX

Enterocytes	75 NX
Colon	186 NX
Rectum	109 NX
Small intestine	42 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	39 NX
Pancreas	39 NX

Extravillous trophoblasts	23 NX
Placenta	23 NX

Fibroblasts	20 NX
Skin	30 NX
Lung	28 NX
Prostate	20 NX
Heart muscle	17 NX
Placenta	15 NX

Glandular cells	72 NX
Prostate	72 NX

Granulocytes	39 NX
Colon	55 NX
Lung	23 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	20 NX
Placenta	19 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	47 NX
Colon	61 NX
Rectum	33 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	10 NX
Testis	10 NX

Macrophages	35 NX
Prostate	57 NX
Skin	49 NX
Lung	36 NX
Testis	34 NX
Kidney	27 NX
Pancreas	23 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	19 NX
Pancreas	19 NX

Mucus-secreting cells	59 NX
Colon	114 NX
Rectum	63 NX
Small intestine	42 NX

Muller glia cells	10 NX
Eye	10 NX

Pancreatic endocrine cells	56 NX
Pancreas	56 NX

Paneth cells	60 NX
Colon	440 NX
Rectum	60 NX
Small intestine	56 NX

Peritubular cells	11 NX
Testis	11 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	5 NX
Eye	5 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	22 NX
Pancreas	23 NX
Prostate	22 NX
Skin	20 NX
Heart muscle	9 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	12 NX
Testis	12 NX

Suprabasal keratinocytes	150 NX
Skin	150 NX

Syncytiotrophoblasts	20 NX
Placenta	20 NX

T-cells	25 NX
Skin	40 NX
Lung	40 NX
Prostate	35 NX
Colon	25 NX
Kidney	15 NX
Liver	12 NX

Undifferentiated cells	41 NX
Colon	117 NX
Small intestine	41 NX
Rectum	32 NX

Urothelial cells	314 NX
Prostate	314 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.