Cell type atlas - PLPP2 - The Human Protein Atlas

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PLPP2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLPP2
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipid phosphatase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ductal cells, Rod photoreceptor cells, Cholangiocytes, Urothelial cells, Ciliated cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (MAIT T-cell, gdT-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, CAPAN-2, OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ductal cells, Rod photoreceptor cells, Cholangiocytes, Urothelial cells, Ciliated cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	7 NX
Lung	7 NX

B-cells	0 NX
Colon	0 NX
Liver	0 NX
Kidney	0 NX

Basal glandular cells	113 NX
Prostate	113 NX

Basal keratinocytes	0 NX
Skin	0 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	189 NX
Liver	189 NX

Ciliated cells	167 NX
Lung	167 NX

Club cells	65 NX
Lung	65 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	0 NX
Placenta	0 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	295 NX
Pancreas	295 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	3 NX
Eye	47 NX
Prostate	24 NX
Placenta	13 NX
Pancreas	11 NX
Lung	6 NX
Testis	3 NX
Heart muscle	0 NX
Skin	0 NX
Liver	0 NX

Enterocytes	108 NX
Small intestine	172 NX
Rectum	140 NX
Colon	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	126 NX
Pancreas	126 NX

Extravillous trophoblasts	5 NX
Placenta	5 NX

Fibroblasts	0 NX
Lung	12 NX
Prostate	6 NX
Placenta	1 NX
Skin	0 NX
Heart muscle	0 NX

Glandular cells	72 NX
Prostate	72 NX

Granulocytes	1 NX
Lung	2 NX
Colon	0 NX

Hepatocytes	0 NX
Liver	0 NX

Hofbauer cells	1 NX
Placenta	1 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	8 NX
Rectum	16 NX
Colon	0 NX

Ito cells	0 NX
Liver	0 NX

Kupffer cells	1 NX
Liver	1 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	0 NX
Testis	0 NX

Macrophages	1 NX
Prostate	7 NX
Lung	3 NX
Pancreas	2 NX
Kidney	1 NX
Testis	0 NX
Skin	0 NX

Melanocytes	0 NX
Skin	0 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	40 NX
Small intestine	53 NX
Rectum	34 NX
Colon	0 NX

Muller glia cells	12 NX
Eye	12 NX

Pancreatic endocrine cells	100 NX
Pancreas	100 NX

Paneth cells	109 NX
Small intestine	126 NX
Rectum	109 NX
Colon	0 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	190 NX
Eye	190 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	0 NX
Pancreas	8 NX
Prostate	7 NX
Heart muscle	0 NX
Skin	0 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	0 NX
Skin	0 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	0 NX
Prostate	9 NX
Lung	2 NX
Kidney	1 NX
Liver	0 NX
Colon	0 NX
Skin	0 NX

Undifferentiated cells	113 NX
Rectum	120 NX
Small intestine	117 NX
Colon	0 NX

Urothelial cells	167 NX
Prostate	167 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.