CACNA1A protein expression summary - The Human Protein Atlas

HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Calcium voltage-gated channel subunit alpha1 A
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CACNA1A (APCA, CACNL1A4, Cav2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enriched (brain)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Horizontal cells, Intestinal endocrine cells, Bipolar cells)
Blood specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Human brain regional enriched (cerebellum)
Cancer prognostic summary	Prognostic marker in pancreatic cancer (favorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular, Membrane (different isoforms)
Subcellular summaryⁱ The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines.	Located in Endoplasmic reticulum
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP).... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Calcium channel, Ion channel, Voltage-gated channel
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Calcium transport, Ion transport, Transport
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Disease mutation, Epilepsy, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	Calcium, Metal-binding
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]... show less

TISSUE ATLASⁱ Summary of data presented in the Tissue Atlas and representative images of protein expression (left) and mRNA expression (right). The images are clickable and will redirect to more Tissue Atlas data. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enriched (brain)
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Distinct expression in Purkinje cells.

SINGLE CELL TYPE ATLASⁱ Summary of data presented in the Cell Type Atlas and an interactive image showing mRNA expression in cell type groups e.g. epithelial cells and germ cells. The image is clickable and will redirect to more Cell Type Atlas data. The Cell Type Atlas contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Horizontal cells, Intestinal endocrine cells, Bipolar cells)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (SCLC-21H, U-87 MG)

PATHOLOGY ATLASⁱ Summary of data presented in the Pathology Atlas , with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology Atlas data. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
	Pancreatic cancer p<0.001
Prognostic summary	Prognostic marker in pancreatic cancer (favorable)
Cancer specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in some

BRAIN ATLASⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Cellular locationⁱ Manually selected location of the protein positivity, observed by immunofluorescence staining in mouse brain. Read more	Soma, dendrite, axon and synapse in neurons. Choroid plexus of ependymal cells.
Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Region enriched (cerebellum)
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

BLOOD ATLASⁱ Summary of data presented in the Blood Atlas and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more Blood Atlas data. The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e.g. B-cells and granulocytes. Analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) and proteins detected in human blood are also presented. Read more

Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No

CELL ATLASⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Endoplasmic reticulum
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data. Read more	NA

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CACNA1A (HGNC Symbol)
Synonyms	APCA, CACNL1A4, Cav2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
Description	Calcium voltage-gated channel subunit alpha1 A (HGNC Symbol)
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	13206442 - 13633025
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	22
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes FDA approved drug targets Plasma proteins Transporters Voltage-gated ion channels
Ensembl	ENSG00000141837 (version 92.38)
Entrez gene	773
UniProt	O00555 (UniProt - Evidence at protein level)
neXtProt	NX_O00555
Antibodypedia	CACNA1A antibodies

PROTEIN BROWSERⁱ

CACNA1A-201

CACNA1A-202

CACNA1A-205

CACNA1A-206

CACNA1A-209

CACNA1A-211

CACNA1A-214

CACNA1A-215

CACNA1A-218

CACNA1A-221

CACNA1A-225

CACNA1A-226

CACNA1A-227

CACNA1A-238

CACNA1A-239

CACNA1A-240

CACNA1A-246

CACNA1A-247

CACNA1A-251

CACNA1A-253

CACNA1A-257

CACNA1A-258

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA1A-201 ENSP00000353362 ENST00000360228	O00555 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008219 [cell death] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019905 [syntaxin binding] GO:0034765 [regulation of ion transmembrane transport] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:1904645 [response to amyloid-beta] GO:1904646 [cellular response to amyloid-beta] Show all	2506 aa 282.6 kDa	No	>9
CACNA1A-202 ENSP00000460092 ENST00000573710	A0A1C7CYY9 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2508 aa 282.6 kDa	No	>9
CACNA1A-205 ENSP00000459963 ENST00000574974	I3L2V5 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	103 aa 11.2 kDa	No	2
CACNA1A-206 ENSP00000465598 ENST00000585802	K7EKF7 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	881 aa 98.8 kDa	No	3
CACNA1A-209 ENSP00000467729 ENST00000587525	K7EQ95 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	981 aa 110.4 kDa	No	6
CACNA1A-211 ENSP00000464729 ENST00000592864	K7EIF8 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		35 aa 4 kDa	No	0
CACNA1A-214 ENSP00000479983 ENST00000614285	A0A087WW63 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0045202 [synapse] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0098793 [presynapse] Show all	2512 aa 283.1 kDa	No	>9
CACNA1A-215 ENSP00000490001 ENST00000635727	A0A1B0GU81 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2507 aa 282.6 kDa	No	>9
CACNA1A-218 ENSP00000490323 ENST00000635895	O00555 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008219 [cell death] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019905 [syntaxin binding] GO:0034765 [regulation of ion transmembrane transport] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:1904645 [response to amyloid-beta] GO:1904646 [cellular response to amyloid-beta] Show all	2261 aa 256.9 kDa	No	>9
CACNA1A-221 ENSP00000490223 ENST00000636012	A0A1B0GUS3 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2495 aa 281.2 kDa	No	>9
CACNA1A-225 ENSP00000489992 ENST00000636389	A0A1B0GU74 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2302 aa 261.4 kDa	No	>9
CACNA1A-226 ENSP00000490173 ENST00000636473	A0A1B0GUM7 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	550 aa 63.3 kDa	No	3
CACNA1A-227 ENSP00000490578 ENST00000636549	B5TYJ1 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2263 aa 257.1 kDa	No	>9
CACNA1A-238 ENSP00000489777 ENST00000637276	O00555 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008219 [cell death] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019905 [syntaxin binding] GO:0034765 [regulation of ion transmembrane transport] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:1904645 [response to amyloid-beta] GO:1904646 [cellular response to amyloid-beta] Show all	2249 aa 255.5 kDa	No	>9
CACNA1A-239 ENSP00000489692 ENST00000637297	A0A1B0GTG6 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	212 aa 24.6 kDa	No	2
CACNA1A-240 ENSP00000490617 ENST00000637432	A0A1B0GVQ9 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2266 aa 257.4 kDa	No	>9
CACNA1A-246 ENSP00000489861 ENST00000637736	A0A1B0GTW2 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2460 aa 277 kDa	No	>9
CACNA1A-247 ENSP00000489778 ENST00000637769	A0A1B0GTN7 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2507 aa 282.5 kDa	No	>9
CACNA1A-251 ENSP00000490686 ENST00000637819	A0A1B0GVX1 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	459 aa 53.1 kDa	No	6
CACNA1A-253 ENSP00000489715 ENST00000637927	A0A1B0GTI4 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	2262 aa 256.9 kDa	No	>9
CACNA1A-257 ENSP00000489913 ENST00000638009	O00555 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha-1A Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008219 [cell death] GO:0008331 [high voltage-gated calcium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019905 [syntaxin binding] GO:0034765 [regulation of ion transmembrane transport] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:1904645 [response to amyloid-beta] GO:1904646 [cellular response to amyloid-beta] Show all	2261 aa 256.8 kDa	No	>9
CACNA1A-258 ENSP00000489829 ENST00000638029	A0A087WW63 [Direct mapping] Voltage-dependent P/Q-type calcium channel subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0001505 [regulation of neurotransmitter levels] GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005262 [calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [chemical synaptic transmission] GO:0007270 [neuron-neuron synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0007416 [synapse assembly] GO:0007628 [adult walking behavior] GO:0008331 [high voltage-gated calcium channel activity] GO:0010817 [regulation of hormone levels] GO:0014051 [gamma-aminobutyric acid secretion] GO:0014056 [regulation of acetylcholine secretion, neurotransmission] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017156 [calcium ion regulated exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019226 [transmission of nerve impulse] GO:0021522 [spinal cord motor neuron differentiation] GO:0021590 [cerebellum maturation] GO:0021679 [cerebellar molecular layer development] GO:0021680 [cerebellar Purkinje cell layer development] GO:0021702 [cerebellar Purkinje cell differentiation] GO:0021750 [vestibular nucleus development] GO:0021953 [central nervous system neuron differentiation] GO:0030425 [dendrite] GO:0030644 [cellular chloride ion homeostasis] GO:0031335 [regulation of sulfur amino acid metabolic process] GO:0032353 [negative regulation of hormone biosynthetic process] GO:0034765 [regulation of ion transmembrane transport] GO:0035249 [synaptic transmission, glutamatergic] GO:0042391 [regulation of membrane potential] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043113 [receptor clustering] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045202 [synapse] GO:0048265 [response to pain] GO:0048266 [behavioral response to pain] GO:0048791 [calcium ion-regulated exocytosis of neurotransmitter] GO:0048813 [dendrite morphogenesis] GO:0050770 [regulation of axonogenesis] GO:0050877 [nervous system process] GO:0050883 [musculoskeletal movement, spinal reflex action] GO:0050885 [neuromuscular process controlling balance] GO:0050905 [neuromuscular process] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0060024 [rhythmic synaptic transmission] GO:0070588 [calcium ion transmembrane transport] GO:0098793 [presynapse] Show all	2512 aa 283.1 kDa	No	>9