Cell type atlas - AFG3L2 - The Human Protein Atlas

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AFG3L2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AFG3L2
Gene descriptionⁱ Full gene name according to HGNC.	AFG3 like matrix AAA peptidase subunit 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	28 NX
Colon	43 NX
Liver	19 NX
Kidney	18 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	47 NX
Eye	47 NX

Cardiomyocytes	69 NX
Heart muscle	69 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	28 NX
Lung	28 NX

Club cells	33 NX
Lung	33 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	47 NX
Eye	47 NX

Cytotrophoblasts	50 NX
Placenta	50 NX

Distal tubular cells	61 NX
Kidney	61 NX

Ductal cells	33 NX
Pancreas	33 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	23 NX
Heart muscle	32 NX
Testis	32 NX
Eye	28 NX
Liver	27 NX
Pancreas	25 NX
Lung	23 NX
Placenta	20 NX
Prostate	19 NX
Skin	17 NX

Enterocytes	78 NX
Rectum	80 NX
Small intestine	79 NX
Colon	72 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	24 NX
Lung	46 NX
Heart muscle	41 NX
Placenta	27 NX
Prostate	24 NX
Skin	14 NX

Glandular cells	25 NX
Prostate	25 NX

Granulocytes	14 NX
Lung	19 NX
Colon	9 NX

Hepatocytes	72 NX
Liver	72 NX

Hofbauer cells	33 NX
Placenta	33 NX

Horizontal cells	29 NX
Eye	29 NX

Intestinal endocrine cells	38 NX
Rectum	52 NX
Colon	24 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	22 NX
Liver	22 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	26 NX
Pancreas	56 NX
Lung	36 NX
Testis	32 NX
Prostate	24 NX
Kidney	22 NX
Skin	18 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	21 NX
Pancreas	21 NX

Mucus-secreting cells	72 NX
Colon	83 NX
Rectum	71 NX
Small intestine	67 NX

Muller glia cells	29 NX
Eye	29 NX

Pancreatic endocrine cells	36 NX
Pancreas	36 NX

Paneth cells	32 NX
Rectum	64 NX
Colon	32 NX
Small intestine	21 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	54 NX
Kidney	54 NX

Rod photoreceptor cells	55 NX
Eye	55 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	21 NX
Pancreas	28 NX
Prostate	21 NX
Heart muscle	17 NX
Skin	16 NX

Spermatocytes	48 NX
Testis	48 NX

Spermatogonia	72 NX
Testis	72 NX

Suprabasal keratinocytes	27 NX
Skin	27 NX

Syncytiotrophoblasts	78 NX
Placenta	78 NX

T-cells	18 NX
Colon	32 NX
Kidney	22 NX
Lung	20 NX
Prostate	18 NX
Liver	13 NX
Skin	13 NX

Undifferentiated cells	75 NX
Rectum	87 NX
Colon	75 NX
Small intestine	72 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.