Cell type atlas - TCF25 - The Human Protein Atlas

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TCF25

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TCF25
Gene descriptionⁱ Full gene name according to HGNC.	Transcription factor 25
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	149 NX
Lung	149 NX

Alveolar cells type 2	149 NX
Lung	149 NX

B-cells	162 NX
Kidney	183 NX
Colon	164 NX
Liver	150 NX

Basal glandular cells	135 NX
Prostate	135 NX

Basal keratinocytes	91 NX
Skin	91 NX

Bipolar cells	330 NX
Eye	330 NX

Cardiomyocytes	76 NX
Heart muscle	76 NX

Cholangiocytes	110 NX
Liver	110 NX

Ciliated cells	179 NX
Lung	179 NX

Club cells	127 NX
Lung	127 NX

Collecting duct cells	157 NX
Kidney	157 NX

Cone photoreceptor cells	261 NX
Eye	261 NX

Cytotrophoblasts	184 NX
Placenta	184 NX

Distal tubular cells	126 NX
Kidney	126 NX

Ductal cells	98 NX
Pancreas	98 NX

Early spermatids	219 NX
Testis	219 NX

Endothelial cells	125 NX
Eye	175 NX
Placenta	157 NX
Testis	153 NX
Prostate	135 NX
Lung	125 NX
Skin	122 NX
Liver	115 NX
Heart muscle	104 NX
Pancreas	82 NX

Enterocytes	176 NX
Colon	223 NX
Small intestine	155 NX
Rectum	110 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	132 NX
Pancreas	132 NX

Extravillous trophoblasts	261 NX
Placenta	261 NX

Fibroblasts	155 NX
Placenta	171 NX
Prostate	155 NX
Lung	155 NX
Skin	135 NX
Heart muscle	79 NX

Glandular cells	152 NX
Prostate	152 NX

Granulocytes	167 NX
Lung	195 NX
Colon	138 NX

Hepatocytes	127 NX
Liver	127 NX

Hofbauer cells	139 NX
Placenta	139 NX

Horizontal cells	439 NX
Eye	439 NX

Intestinal endocrine cells	142 NX
Colon	177 NX
Rectum	108 NX

Ito cells	114 NX
Liver	114 NX

Kupffer cells	137 NX
Liver	137 NX

Late spermatids	248 NX
Testis	248 NX

Leydig cells	161 NX
Testis	161 NX

Macrophages	149 NX
Lung	238 NX
Prostate	173 NX
Testis	151 NX
Kidney	147 NX
Skin	133 NX
Pancreas	82 NX

Melanocytes	177 NX
Skin	177 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	162 NX
Pancreas	162 NX

Mucus-secreting cells	142 NX
Colon	329 NX
Small intestine	154 NX
Rectum	135 NX

Muller glia cells	162 NX
Eye	162 NX

Pancreatic endocrine cells	106 NX
Pancreas	106 NX

Paneth cells	151 NX
Colon	207 NX
Small intestine	151 NX
Rectum	127 NX

Peritubular cells	173 NX
Testis	173 NX

Proximal tubular cells	108 NX
Kidney	108 NX

Rod photoreceptor cells	257 NX
Eye	257 NX

Sertoli cells	155 NX
Testis	155 NX

Smooth muscle cells	136 NX
Prostate	151 NX
Heart muscle	136 NX
Skin	133 NX
Pancreas	111 NX

Spermatocytes	171 NX
Testis	171 NX

Spermatogonia	64 NX
Testis	64 NX

Suprabasal keratinocytes	91 NX
Skin	91 NX

Syncytiotrophoblasts	451 NX
Placenta	451 NX

T-cells	173 NX
Lung	265 NX
Prostate	201 NX
Kidney	200 NX
Colon	181 NX
Skin	172 NX
Liver	153 NX

Undifferentiated cells	134 NX
Colon	233 NX
Small intestine	133 NX
Rectum	126 NX

Urothelial cells	143 NX
Prostate	143 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.