Cell type atlas - SEC11A - The Human Protein Atlas

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SEC11A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SEC11A
Gene descriptionⁱ Full gene name according to HGNC.	SEC11 homolog A, signal peptidase complex subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	83 NX
Lung	83 NX

Alveolar cells type 2	83 NX
Lung	83 NX

B-cells	129 NX
Liver	167 NX
Colon	133 NX
Kidney	116 NX

Basal glandular cells	147 NX
Prostate	147 NX

Basal keratinocytes	95 NX
Skin	95 NX

Bipolar cells	26 NX
Eye	26 NX

Cardiomyocytes	57 NX
Heart muscle	57 NX

Cholangiocytes	214 NX
Liver	214 NX

Ciliated cells	68 NX
Lung	68 NX

Club cells	101 NX
Lung	101 NX

Collecting duct cells	122 NX
Kidney	122 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	265 NX
Placenta	265 NX

Distal tubular cells	202 NX
Kidney	202 NX

Ductal cells	212 NX
Pancreas	212 NX

Early spermatids	36 NX
Testis	36 NX

Endothelial cells	236 NX
Placenta	283 NX
Prostate	274 NX
Skin	267 NX
Testis	258 NX
Pancreas	236 NX
Liver	169 NX
Eye	115 NX
Lung	99 NX
Heart muscle	50 NX

Enterocytes	104 NX
Small intestine	123 NX
Rectum	117 NX
Colon	75 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	216 NX
Pancreas	216 NX

Extravillous trophoblasts	493 NX
Placenta	493 NX

Fibroblasts	217 NX
Placenta	264 NX
Prostate	235 NX
Skin	213 NX
Lung	94 NX
Heart muscle	65 NX

Glandular cells	158 NX
Prostate	158 NX

Granulocytes	218 NX
Colon	312 NX
Lung	123 NX

Hepatocytes	143 NX
Liver	143 NX

Hofbauer cells	325 NX
Placenta	325 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	151 NX
Colon	167 NX
Rectum	136 NX

Ito cells	168 NX
Liver	168 NX

Kupffer cells	353 NX
Liver	353 NX

Late spermatids	68 NX
Testis	68 NX

Leydig cells	277 NX
Testis	277 NX

Macrophages	291 NX
Prostate	674 NX
Testis	545 NX
Kidney	367 NX
Skin	291 NX
Lung	206 NX
Pancreas	197 NX

Melanocytes	150 NX
Skin	150 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	268 NX
Pancreas	268 NX

Mucus-secreting cells	173 NX
Colon	266 NX
Rectum	212 NX
Small intestine	100 NX

Muller glia cells	64 NX
Eye	64 NX

Pancreatic endocrine cells	170 NX
Pancreas	170 NX

Paneth cells	104 NX
Rectum	191 NX
Colon	104 NX
Small intestine	74 NX

Peritubular cells	156 NX
Testis	156 NX

Proximal tubular cells	255 NX
Kidney	255 NX

Rod photoreceptor cells	33 NX
Eye	33 NX

Sertoli cells	168 NX
Testis	168 NX

Smooth muscle cells	122 NX
Pancreas	264 NX
Prostate	177 NX
Skin	121 NX
Heart muscle	85 NX

Spermatocytes	177 NX
Testis	177 NX

Spermatogonia	143 NX
Testis	143 NX

Suprabasal keratinocytes	105 NX
Skin	105 NX

Syncytiotrophoblasts	256 NX
Placenta	256 NX

T-cells	159 NX
Prostate	253 NX
Kidney	183 NX
Liver	182 NX
Colon	157 NX
Skin	152 NX
Lung	96 NX

Undifferentiated cells	215 NX
Colon	222 NX
Rectum	217 NX
Small intestine	158 NX

Urothelial cells	195 NX
Prostate	195 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.