Cell type atlas - TMX1 - The Human Protein Atlas

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TMX1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMX1
Gene descriptionⁱ Full gene name according to HGNC.	Thioredoxin related transmembrane protein 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	36 NX
Liver	42 NX
Colon	36 NX
Kidney	36 NX

Basal glandular cells	52 NX
Prostate	52 NX

Basal keratinocytes	97 NX
Skin	97 NX

Bipolar cells	11 NX
Eye	11 NX

Cardiomyocytes	7 NX
Heart muscle	7 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	38 NX
Lung	38 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	67 NX
Placenta	67 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	51 NX
Pancreas	51 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	45 NX
Pancreas	79 NX
Skin	56 NX
Prostate	49 NX
Placenta	45 NX
Heart muscle	44 NX
Testis	35 NX
Lung	29 NX
Eye	24 NX
Liver	16 NX

Enterocytes	24 NX
Rectum	45 NX
Small intestine	26 NX
Colon	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	59 NX
Pancreas	59 NX

Extravillous trophoblasts	120 NX
Placenta	120 NX

Fibroblasts	52 NX
Skin	59 NX
Placenta	52 NX
Prostate	38 NX
Heart muscle	37 NX
Lung	32 NX

Glandular cells	42 NX
Prostate	42 NX

Granulocytes	42 NX
Lung	56 NX
Colon	28 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	67 NX
Placenta	67 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	17 NX
Colon	17 NX
Rectum	16 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	52 NX
Liver	52 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	72 NX
Skin	81 NX
Pancreas	75 NX
Prostate	72 NX
Kidney	64 NX
Lung	60 NX
Testis	59 NX

Melanocytes	52 NX
Skin	52 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	61 NX
Pancreas	61 NX

Mucus-secreting cells	31 NX
Rectum	33 NX
Small intestine	24 NX
Colon	19 NX

Muller glia cells	24 NX
Eye	24 NX

Pancreatic endocrine cells	42 NX
Pancreas	42 NX

Paneth cells	53 NX
Rectum	57 NX
Small intestine	53 NX
Colon	12 NX

Peritubular cells	27 NX
Testis	27 NX

Proximal tubular cells	27 NX
Kidney	27 NX

Rod photoreceptor cells	32 NX
Eye	32 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	51 NX
Pancreas	79 NX
Heart muscle	62 NX
Skin	49 NX
Prostate	46 NX

Spermatocytes	43 NX
Testis	43 NX

Spermatogonia	74 NX
Testis	74 NX

Suprabasal keratinocytes	85 NX
Skin	85 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	59 NX
Kidney	68 NX
Skin	65 NX
Prostate	61 NX
Colon	59 NX
Lung	45 NX
Liver	35 NX

Undifferentiated cells	45 NX
Small intestine	50 NX
Rectum	45 NX
Colon	44 NX

Urothelial cells	57 NX
Prostate	57 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.