Cell type atlas - DENR - The Human Protein Atlas

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DENR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DENR
Gene descriptionⁱ Full gene name according to HGNC.	Density regulated re-initiation and release factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	64 NX
Colon	72 NX
Liver	69 NX
Kidney	45 NX

Basal glandular cells	55 NX
Prostate	55 NX

Basal keratinocytes	64 NX
Skin	64 NX

Bipolar cells	36 NX
Eye	36 NX

Cardiomyocytes	61 NX
Heart muscle	61 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	49 NX
Lung	49 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	62 NX
Placenta	62 NX

Distal tubular cells	55 NX
Kidney	55 NX

Ductal cells	64 NX
Pancreas	64 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	43 NX
Lung	82 NX
Pancreas	79 NX
Testis	58 NX
Placenta	56 NX
Liver	43 NX
Prostate	37 NX
Eye	37 NX
Skin	36 NX
Heart muscle	31 NX

Enterocytes	36 NX
Rectum	38 NX
Small intestine	37 NX
Colon	33 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	53 NX
Pancreas	53 NX

Extravillous trophoblasts	110 NX
Placenta	110 NX

Fibroblasts	43 NX
Lung	67 NX
Placenta	46 NX
Heart muscle	43 NX
Prostate	42 NX
Skin	38 NX

Glandular cells	48 NX
Prostate	48 NX

Granulocytes	42 NX
Lung	47 NX
Colon	37 NX

Hepatocytes	45 NX
Liver	45 NX

Hofbauer cells	50 NX
Placenta	50 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	81 NX
Colon	102 NX
Rectum	61 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	45 NX
Liver	45 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	47 NX
Testis	47 NX

Macrophages	51 NX
Lung	78 NX
Testis	59 NX
Skin	48 NX
Prostate	43 NX
Kidney	42 NX
Pancreas	30 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	55 NX
Pancreas	55 NX

Mucus-secreting cells	49 NX
Rectum	49 NX
Colon	47 NX
Small intestine	45 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	68 NX
Pancreas	68 NX

Paneth cells	46 NX
Rectum	53 NX
Small intestine	46 NX
Colon	23 NX

Peritubular cells	43 NX
Testis	43 NX

Proximal tubular cells	54 NX
Kidney	54 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	47 NX
Pancreas	71 NX
Heart muscle	47 NX
Skin	47 NX
Prostate	26 NX

Spermatocytes	52 NX
Testis	52 NX

Spermatogonia	143 NX
Testis	143 NX

Suprabasal keratinocytes	57 NX
Skin	57 NX

Syncytiotrophoblasts	51 NX
Placenta	51 NX

T-cells	52 NX
Lung	71 NX
Colon	57 NX
Liver	54 NX
Kidney	45 NX
Skin	44 NX
Prostate	26 NX

Undifferentiated cells	54 NX
Colon	59 NX
Small intestine	55 NX
Rectum	50 NX

Urothelial cells	44 NX
Prostate	44 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.