Cell type atlas - NUP58 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NUP58

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUP58
Gene descriptionⁱ Full gene name according to HGNC.	Nucleoporin 58
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	80 NX
Lung	80 NX

B-cells	9 NX
Kidney	18 NX
Liver	11 NX
Colon	0 NX

Basal glandular cells	22 NX
Prostate	22 NX

Basal keratinocytes	0 NX
Skin	0 NX

Bipolar cells	33 NX
Eye	33 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	51 NX
Eye	51 NX

Cytotrophoblasts	22 NX
Placenta	22 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	13 NX
Pancreas	13 NX

Early spermatids	104 NX
Testis	104 NX

Endothelial cells	18 NX
Prostate	42 NX
Eye	31 NX
Lung	20 NX
Pancreas	18 NX
Liver	18 NX
Placenta	18 NX
Testis	13 NX
Heart muscle	0 NX
Skin	0 NX

Enterocytes	8 NX
Rectum	15 NX
Small intestine	10 NX
Colon	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	9 NX
Pancreas	9 NX

Extravillous trophoblasts	33 NX
Placenta	33 NX

Fibroblasts	12 NX
Prostate	50 NX
Lung	26 NX
Placenta	15 NX
Skin	0 NX
Heart muscle	0 NX

Glandular cells	29 NX
Prostate	29 NX

Granulocytes	22 NX
Lung	44 NX
Colon	0 NX

Hepatocytes	24 NX
Liver	24 NX

Hofbauer cells	21 NX
Placenta	21 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	9 NX
Rectum	19 NX
Colon	0 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	39 NX
Liver	39 NX

Late spermatids	182 NX
Testis	182 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	32 NX
Lung	44 NX
Kidney	37 NX
Prostate	34 NX
Pancreas	30 NX
Testis	25 NX
Skin	0 NX

Melanocytes	0 NX
Skin	0 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	15 NX
Pancreas	15 NX

Mucus-secreting cells	19 NX
Small intestine	19 NX
Rectum	18 NX
Colon	0 NX

Muller glia cells	29 NX
Eye	29 NX

Pancreatic endocrine cells	15 NX
Pancreas	15 NX

Paneth cells	4 NX
Rectum	15 NX
Small intestine	4 NX
Colon	0 NX

Peritubular cells	23 NX
Testis	23 NX

Proximal tubular cells	23 NX
Kidney	23 NX

Rod photoreceptor cells	44 NX
Eye	44 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	0 NX
Prostate	33 NX
Pancreas	17 NX
Heart muscle	0 NX
Skin	0 NX

Spermatocytes	78 NX
Testis	78 NX

Spermatogonia	80 NX
Testis	80 NX

Suprabasal keratinocytes	0 NX
Skin	0 NX

Syncytiotrophoblasts	33 NX
Placenta	33 NX

T-cells	15 NX
Prostate	48 NX
Lung	27 NX
Liver	18 NX
Kidney	10 NX
Colon	0 NX
Skin	0 NX

Undifferentiated cells	18 NX
Rectum	19 NX
Small intestine	19 NX
Colon	0 NX

Urothelial cells	24 NX
Prostate	24 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.