Cell type atlas - TDG - The Human Protein Atlas

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TDG

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TDG
Gene descriptionⁱ Full gene name according to HGNC.	Thymine DNA glycosylase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	18 NX
Lung	18 NX

B-cells	41 NX
Liver	62 NX
Colon	51 NX
Kidney	31 NX

Basal glandular cells	34 NX
Prostate	34 NX

Basal keratinocytes	70 NX
Skin	70 NX

Bipolar cells	46 NX
Eye	45 NX

Cardiomyocytes	23 NX
Heart muscle	23 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	40 NX
Lung	40 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	58 NX
Placenta	58 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	66 NX
Pancreas	66 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	44 NX
Liver	54 NX
Pancreas	54 NX
Eye	50 NX
Lung	50 NX
Prostate	45 NX
Placenta	44 NX
Skin	43 NX
Heart muscle	36 NX
Testis	32 NX

Enterocytes	27 NX
Rectum	30 NX
Colon	28 NX
Small intestine	25 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	47 NX
Pancreas	47 NX

Extravillous trophoblasts	71 NX
Placenta	71 NX

Fibroblasts	38 NX
Lung	45 NX
Heart muscle	40 NX
Prostate	39 NX
Skin	38 NX
Placenta	37 NX

Glandular cells	38 NX
Prostate	38 NX

Granulocytes	38 NX
Lung	58 NX
Colon	18 NX

Hepatocytes	30 NX
Liver	30 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	78 NX
Colon	105 NX
Rectum	52 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	39 NX
Liver	39 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	25 NX
Testis	25 NX

Macrophages	39 NX
Prostate	66 NX
Lung	55 NX
Kidney	40 NX
Skin	37 NX
Pancreas	33 NX
Testis	31 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	40 NX
Pancreas	40 NX

Mucus-secreting cells	40 NX
Colon	69 NX
Rectum	43 NX
Small intestine	35 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	65 NX
Pancreas	65 NX

Paneth cells	35 NX
Rectum	40 NX
Colon	35 NX
Small intestine	32 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	31 NX
Pancreas	53 NX
Skin	36 NX
Prostate	29 NX
Heart muscle	26 NX

Spermatocytes	10 NX
Testis	10 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	90 NX
Skin	90 NX

Syncytiotrophoblasts	131 NX
Placenta	131 NX

T-cells	40 NX
Lung	66 NX
Skin	51 NX
Colon	47 NX
Liver	37 NX
Kidney	37 NX
Prostate	31 NX

Undifferentiated cells	39 NX
Rectum	39 NX
Small intestine	39 NX
Colon	28 NX

Urothelial cells	48 NX
Prostate	48 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.