Cell type atlas - PPA2 - The Human Protein Atlas

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PPA2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPA2
Gene descriptionⁱ Full gene name according to HGNC.	Pyrophosphatase (inorganic) 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	30 NX
Kidney	58 NX
Colon	25 NX
Liver	17 NX

Basal glandular cells	72 NX
Prostate	72 NX

Basal keratinocytes	44 NX
Skin	44 NX

Bipolar cells	30 NX
Eye	30 NX

Cardiomyocytes	56 NX
Heart muscle	56 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	107 NX
Placenta	107 NX

Distal tubular cells	224 NX
Kidney	224 NX

Ductal cells	100 NX
Pancreas	100 NX

Early spermatids	91 NX
Testis	91 NX

Endothelial cells	35 NX
Placenta	45 NX
Pancreas	43 NX
Lung	41 NX
Testis	39 NX
Prostate	37 NX
Skin	35 NX
Eye	30 NX
Liver	27 NX
Heart muscle	25 NX

Enterocytes	73 NX
Small intestine	95 NX
Rectum	76 NX
Colon	56 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	105 NX
Pancreas	105 NX

Extravillous trophoblasts	79 NX
Placenta	79 NX

Fibroblasts	32 NX
Placenta	40 NX
Heart muscle	35 NX
Prostate	31 NX
Skin	31 NX
Lung	25 NX

Glandular cells	70 NX
Prostate	70 NX

Granulocytes	44 NX
Lung	51 NX
Colon	37 NX

Hepatocytes	60 NX
Liver	60 NX

Hofbauer cells	74 NX
Placenta	74 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	63 NX
Colon	75 NX
Rectum	52 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	37 NX
Liver	37 NX

Late spermatids	96 NX
Testis	96 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	66 NX
Pancreas	94 NX
Skin	88 NX
Kidney	63 NX
Lung	62 NX
Testis	59 NX
Prostate	46 NX

Melanocytes	73 NX
Skin	73 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	47 NX
Pancreas	47 NX

Mucus-secreting cells	87 NX
Colon	113 NX
Rectum	88 NX
Small intestine	73 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	66 NX
Pancreas	66 NX

Paneth cells	98 NX
Small intestine	116 NX
Rectum	98 NX
Colon	35 NX

Peritubular cells	30 NX
Testis	30 NX

Proximal tubular cells	222 NX
Kidney	222 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	50 NX
Pancreas	64 NX
Skin	52 NX
Prostate	43 NX
Heart muscle	36 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	50 NX
Skin	50 NX

Syncytiotrophoblasts	71 NX
Placenta	71 NX

T-cells	46 NX
Kidney	59 NX
Lung	49 NX
Liver	47 NX
Skin	40 NX
Colon	35 NX
Prostate	26 NX

Undifferentiated cells	110 NX
Small intestine	149 NX
Colon	144 NX
Rectum	105 NX

Urothelial cells	76 NX
Prostate	76 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.