Cell type atlas - SEC31A - The Human Protein Atlas

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SEC31A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SEC31A
Gene descriptionⁱ Full gene name according to HGNC.	SEC31 homolog A, COPII coat complex component
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	28

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	98 NX
Lung	98 NX

Alveolar cells type 2	74 NX
Lung	74 NX

B-cells	45 NX
Liver	57 NX
Colon	48 NX
Kidney	18 NX

Basal glandular cells	45 NX
Prostate	45 NX

Basal keratinocytes	54 NX
Skin	54 NX

Bipolar cells	48 NX
Eye	48 NX

Cardiomyocytes	70 NX
Heart muscle	70 NX

Cholangiocytes	51 NX
Liver	51 NX

Ciliated cells	80 NX
Lung	80 NX

Club cells	121 NX
Lung	121 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	51 NX
Eye	51 NX

Cytotrophoblasts	48 NX
Placenta	48 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	55 NX
Pancreas	55 NX

Early spermatids	22 NX
Testis	22 NX

Endothelial cells	50 NX
Lung	90 NX
Heart muscle	90 NX
Prostate	62 NX
Placenta	59 NX
Skin	48 NX
Testis	45 NX
Eye	38 NX
Liver	34 NX
Pancreas	29 NX

Enterocytes	63 NX
Small intestine	112 NX
Rectum	57 NX
Colon	44 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	62 NX
Pancreas	62 NX

Extravillous trophoblasts	71 NX
Placenta	71 NX

Fibroblasts	94 NX
Lung	152 NX
Heart muscle	126 NX
Skin	94 NX
Placenta	89 NX
Prostate	87 NX

Glandular cells	75 NX
Prostate	75 NX

Granulocytes	71 NX
Lung	114 NX
Colon	28 NX

Hepatocytes	87 NX
Liver	87 NX

Hofbauer cells	41 NX
Placenta	41 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	37 NX
Colon	41 NX
Rectum	33 NX

Ito cells	58 NX
Liver	58 NX

Kupffer cells	43 NX
Liver	43 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	129 NX
Testis	129 NX

Macrophages	48 NX
Lung	85 NX
Skin	51 NX
Prostate	48 NX
Kidney	47 NX
Pancreas	44 NX
Testis	44 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	43 NX
Pancreas	43 NX

Mucus-secreting cells	90 NX
Colon	113 NX
Rectum	85 NX
Small intestine	84 NX

Muller glia cells	44 NX
Eye	44 NX

Pancreatic endocrine cells	64 NX
Pancreas	64 NX

Paneth cells	39 NX
Rectum	53 NX
Small intestine	39 NX
Colon	35 NX

Peritubular cells	119 NX
Testis	119 NX

Proximal tubular cells	56 NX
Kidney	56 NX

Rod photoreceptor cells	62 NX
Eye	62 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	81 NX
Heart muscle	128 NX
Pancreas	86 NX
Prostate	81 NX
Skin	64 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	33 NX
Testis	33 NX

Suprabasal keratinocytes	65 NX
Skin	65 NX

Syncytiotrophoblasts	68 NX
Placenta	68 NX

T-cells	35 NX
Lung	72 NX
Kidney	47 NX
Colon	41 NX
Skin	36 NX
Prostate	35 NX
Liver	27 NX

Undifferentiated cells	47 NX
Colon	55 NX
Rectum	47 NX
Small intestine	41 NX

Urothelial cells	74 NX
Prostate	74 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.