Cell type atlas - USP8 - The Human Protein Atlas

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USP8

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP8
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	105 NX
Lung	105 NX

B-cells	61 NX
Colon	70 NX
Kidney	67 NX
Liver	49 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	26 NX
Skin	26 NX

Bipolar cells	52 NX
Eye	52 NX

Cardiomyocytes	62 NX
Heart muscle	62 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	147 NX
Lung	147 NX

Club cells	89 NX
Lung	89 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	65 NX
Eye	65 NX

Cytotrophoblasts	50 NX
Placenta	50 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	44 NX
Pancreas	44 NX

Early spermatids	53 NX
Testis	53 NX

Endothelial cells	45 NX
Heart muscle	83 NX
Pancreas	54 NX
Testis	54 NX
Lung	47 NX
Prostate	45 NX
Liver	43 NX
Placenta	39 NX
Eye	30 NX
Skin	24 NX

Enterocytes	71 NX
Small intestine	73 NX
Colon	71 NX
Rectum	65 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	45 NX
Pancreas	45 NX

Extravillous trophoblasts	38 NX
Placenta	38 NX

Fibroblasts	35 NX
Lung	109 NX
Prostate	49 NX
Heart muscle	48 NX
Placenta	36 NX
Skin	27 NX

Glandular cells	39 NX
Prostate	39 NX

Granulocytes	83 NX
Lung	102 NX
Colon	64 NX

Hepatocytes	46 NX
Liver	46 NX

Hofbauer cells	40 NX
Placenta	40 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	51 NX
Rectum	52 NX
Colon	51 NX

Ito cells	53 NX
Liver	53 NX

Kupffer cells	59 NX
Liver	59 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	50 NX
Testis	50 NX

Macrophages	49 NX
Lung	143 NX
Pancreas	68 NX
Testis	52 NX
Prostate	46 NX
Kidney	42 NX
Skin	34 NX

Melanocytes	39 NX
Skin	39 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	52 NX
Pancreas	52 NX

Mucus-secreting cells	54 NX
Small intestine	70 NX
Colon	69 NX
Rectum	48 NX

Muller glia cells	53 NX
Eye	53 NX

Pancreatic endocrine cells	46 NX
Pancreas	46 NX

Paneth cells	54 NX
Small intestine	70 NX
Rectum	54 NX
Colon	35 NX

Peritubular cells	58 NX
Testis	58 NX

Proximal tubular cells	41 NX
Kidney	41 NX

Rod photoreceptor cells	76 NX
Eye	76 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	43 NX
Heart muscle	99 NX
Prostate	43 NX
Pancreas	43 NX
Skin	35 NX

Spermatocytes	86 NX
Testis	86 NX

Spermatogonia	47 NX
Testis	47 NX

Suprabasal keratinocytes	36 NX
Skin	36 NX

Syncytiotrophoblasts	88 NX
Placenta	88 NX

T-cells	48 NX
Lung	106 NX
Colon	70 NX
Prostate	48 NX
Liver	46 NX
Kidney	45 NX
Skin	31 NX

Undifferentiated cells	55 NX
Small intestine	60 NX
Rectum	55 NX
Colon	52 NX

Urothelial cells	53 NX
Prostate	53 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.