Cell type atlas - ABI2 - The Human Protein Atlas

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ABI2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABI2
Gene descriptionⁱ Full gene name according to HGNC.	Abl interactor 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	25 NX
Lung	24 NX

B-cells	13 NX
Kidney	18 NX
Liver	13 NX
Colon	12 NX

Basal glandular cells	50 NX
Prostate	50 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	106 NX
Eye	105 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	83 NX
Lung	83 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	153 NX
Eye	153 NX

Cytotrophoblasts	19 NX
Placenta	19 NX

Distal tubular cells	28 NX
Kidney	28 NX

Ductal cells	19 NX
Pancreas	19 NX

Early spermatids	102 NX
Testis	102 NX

Endothelial cells	33 NX
Eye	53 NX
Placenta	50 NX
Prostate	46 NX
Testis	43 NX
Liver	32 NX
Pancreas	32 NX
Skin	32 NX
Heart muscle	30 NX
Lung	18 NX

Enterocytes	10 NX
Colon	11 NX
Small intestine	10 NX
Rectum	6 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	14 NX
Placenta	14 NX

Fibroblasts	50 NX
Skin	72 NX
Prostate	65 NX
Lung	50 NX
Placenta	38 NX
Heart muscle	34 NX

Glandular cells	35 NX
Prostate	35 NX

Granulocytes	15 NX
Lung	21 NX
Colon	9 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	14 NX
Placenta	14 NX

Horizontal cells	97 NX
Eye	97 NX

Intestinal endocrine cells	47 NX
Rectum	54 NX
Colon	41 NX

Ito cells	58 NX
Liver	58 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	62 NX
Testis	62 NX

Leydig cells	43 NX
Testis	43 NX

Macrophages	23 NX
Skin	42 NX
Prostate	38 NX
Testis	27 NX
Lung	16 NX
Kidney	16 NX
Pancreas	7 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	9 NX
Small intestine	10 NX
Rectum	10 NX
Colon	7 NX

Muller glia cells	78 NX
Eye	78 NX

Pancreatic endocrine cells	14 NX
Pancreas	14 NX

Paneth cells	18 NX
Colon	20 NX
Small intestine	18 NX
Rectum	15 NX

Peritubular cells	59 NX
Testis	59 NX

Proximal tubular cells	28 NX
Kidney	28 NX

Rod photoreceptor cells	94 NX
Eye	94 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	57 NX
Heart muscle	60 NX
Prostate	57 NX
Skin	57 NX
Pancreas	36 NX

Spermatocytes	71 NX
Testis	71 NX

Spermatogonia	50 NX
Testis	50 NX

Suprabasal keratinocytes	23 NX
Skin	23 NX

Syncytiotrophoblasts	17 NX
Placenta	17 NX

T-cells	18 NX
Skin	30 NX
Prostate	26 NX
Colon	19 NX
Liver	16 NX
Kidney	15 NX
Lung	12 NX

Undifferentiated cells	18 NX
Small intestine	19 NX
Rectum	18 NX
Colon	7 NX

Urothelial cells	32 NX
Prostate	32 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.