Cell type atlas - ARL3 - The Human Protein Atlas

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ARL3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARL3
Gene descriptionⁱ Full gene name according to HGNC.	ADP ribosylation factor like GTPase 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	35 NX
Lung	35 NX

B-cells	25 NX
Kidney	45 NX
Liver	16 NX
Colon	16 NX

Basal glandular cells	62 NX
Prostate	62 NX

Basal keratinocytes	29 NX
Skin	29 NX

Bipolar cells	163 NX
Eye	163 NX

Cardiomyocytes	124 NX
Heart muscle	124 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	234 NX
Lung	234 NX

Club cells	69 NX
Lung	69 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	110 NX
Eye	110 NX

Cytotrophoblasts	38 NX
Placenta	38 NX

Distal tubular cells	199 NX
Kidney	199 NX

Ductal cells	63 NX
Pancreas	63 NX

Early spermatids	31 NX
Testis	31 NX

Endothelial cells	37 NX
Eye	59 NX
Heart muscle	53 NX
Placenta	50 NX
Skin	38 NX
Liver	38 NX
Testis	37 NX
Pancreas	36 NX
Prostate	35 NX
Lung	29 NX

Enterocytes	9 NX
Small intestine	17 NX
Rectum	9 NX
Colon	4 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	39 NX
Pancreas	38 NX

Extravillous trophoblasts	32 NX
Placenta	32 NX

Fibroblasts	64 NX
Heart muscle	97 NX
Placenta	67 NX
Skin	66 NX
Prostate	57 NX
Lung	38 NX

Glandular cells	46 NX
Prostate	46 NX

Granulocytes	32 NX
Colon	37 NX
Lung	28 NX

Hepatocytes	24 NX
Liver	24 NX

Hofbauer cells	55 NX
Placenta	55 NX

Horizontal cells	92 NX
Eye	92 NX

Intestinal endocrine cells	72 NX
Colon	78 NX
Rectum	66 NX

Ito cells	38 NX
Liver	38 NX

Kupffer cells	15 NX
Liver	15 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	32 NX
Pancreas	44 NX
Prostate	34 NX
Skin	34 NX
Kidney	32 NX
Testis	32 NX
Lung	26 NX

Melanocytes	73 NX
Skin	73 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	103 NX
Pancreas	103 NX

Mucus-secreting cells	29 NX
Rectum	34 NX
Colon	27 NX
Small intestine	24 NX

Muller glia cells	161 NX
Eye	161 NX

Pancreatic endocrine cells	30 NX
Pancreas	30 NX

Paneth cells	12 NX
Rectum	18 NX
Colon	12 NX
Small intestine	7 NX

Peritubular cells	98 NX
Testis	98 NX

Proximal tubular cells	175 NX
Kidney	175 NX

Rod photoreceptor cells	242 NX
Eye	242 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	102 NX
Heart muscle	158 NX
Pancreas	109 NX
Prostate	102 NX
Skin	97 NX

Spermatocytes	184 NX
Testis	184 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	28 NX
Skin	28 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	20 NX
Skin	31 NX
Kidney	28 NX
Colon	23 NX
Prostate	22 NX
Lung	20 NX
Liver	6 NX

Undifferentiated cells	27 NX
Small intestine	31 NX
Rectum	22 NX
Colon	11 NX

Urothelial cells	43 NX
Prostate	43 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.