Cell type atlas - ACTR1A - The Human Protein Atlas

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ACTR1A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACTR1A
Gene descriptionⁱ Full gene name according to HGNC.	ARP1 actin related protein 1 homolog A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	21 NX
Colon	28 NX
Liver	26 NX
Kidney	9 NX

Basal glandular cells	21 NX
Prostate	21 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	45 NX
Heart muscle	45 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	46 NX
Placenta	46 NX

Distal tubular cells	46 NX
Kidney	46 NX

Ductal cells	71 NX
Pancreas	71 NX

Early spermatids	41 NX
Testis	41 NX

Endothelial cells	41 NX
Pancreas	82 NX
Placenta	58 NX
Heart muscle	46 NX
Prostate	44 NX
Testis	41 NX
Liver	38 NX
Skin	34 NX
Lung	29 NX
Eye	22 NX

Enterocytes	42 NX
Rectum	51 NX
Colon	45 NX
Small intestine	37 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	68 NX
Pancreas	68 NX

Extravillous trophoblasts	53 NX
Placenta	53 NX

Fibroblasts	36 NX
Placenta	56 NX
Heart muscle	46 NX
Prostate	36 NX
Skin	30 NX
Lung	20 NX

Glandular cells	22 NX
Prostate	21 NX

Granulocytes	31 NX
Lung	35 NX
Colon	28 NX

Hepatocytes	21 NX
Liver	21 NX

Hofbauer cells	65 NX
Placenta	65 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	38 NX
Rectum	42 NX
Colon	34 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	40 NX
Testis	40 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	42 NX
Pancreas	115 NX
Prostate	51 NX
Testis	46 NX
Kidney	44 NX
Skin	37 NX
Lung	34 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	95 NX
Pancreas	95 NX

Mucus-secreting cells	22 NX
Rectum	24 NX
Colon	21 NX
Small intestine	18 NX

Muller glia cells	31 NX
Eye	31 NX

Pancreatic endocrine cells	72 NX
Pancreas	72 NX

Paneth cells	32 NX
Colon	37 NX
Small intestine	32 NX
Rectum	31 NX

Peritubular cells	34 NX
Testis	34 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	22 NX
Eye	22 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	43 NX
Pancreas	112 NX
Heart muscle	69 NX
Prostate	43 NX
Skin	26 NX

Spermatocytes	52 NX
Testis	52 NX

Spermatogonia	11 NX
Testis	11 NX

Suprabasal keratinocytes	28 NX
Skin	28 NX

Syncytiotrophoblasts	88 NX
Placenta	88 NX

T-cells	31 NX
Kidney	45 NX
Skin	35 NX
Colon	32 NX
Liver	30 NX
Lung	29 NX
Prostate	26 NX

Undifferentiated cells	20 NX
Colon	23 NX
Small intestine	20 NX
Rectum	19 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.