Cell type atlas - RAB1A - The Human Protein Atlas

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RAB1A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RAB1A
Gene descriptionⁱ Full gene name according to HGNC.	RAB1A, member RAS oncogene family
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	78 NX
Lung	78 NX

B-cells	68 NX
Colon	78 NX
Liver	72 NX
Kidney	58 NX

Basal glandular cells	291 NX
Prostate	291 NX

Basal keratinocytes	264 NX
Skin	264 NX

Bipolar cells	45 NX
Eye	45 NX

Cardiomyocytes	107 NX
Heart muscle	107 NX

Cholangiocytes	102 NX
Liver	102 NX

Ciliated cells	98 NX
Lung	98 NX

Club cells	82 NX
Lung	82 NX

Collecting duct cells	119 NX
Kidney	119 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	278 NX
Placenta	278 NX

Distal tubular cells	279 NX
Kidney	279 NX

Ductal cells	191 NX
Pancreas	191 NX

Early spermatids	294 NX
Testis	294 NX

Endothelial cells	132 NX
Prostate	241 NX
Skin	178 NX
Placenta	171 NX
Pancreas	136 NX
Testis	132 NX
Lung	123 NX
Liver	106 NX
Heart muscle	91 NX
Eye	77 NX

Enterocytes	150 NX
Colon	177 NX
Rectum	148 NX
Small intestine	145 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	192 NX
Pancreas	192 NX

Extravillous trophoblasts	316 NX
Placenta	316 NX

Fibroblasts	221 NX
Prostate	385 NX
Placenta	228 NX
Skin	223 NX
Heart muscle	135 NX
Lung	84 NX

Glandular cells	287 NX
Prostate	287 NX

Granulocytes	50 NX
Colon	55 NX
Lung	44 NX

Hepatocytes	170 NX
Liver	170 NX

Hofbauer cells	323 NX
Placenta	323 NX

Horizontal cells	56 NX
Eye	56 NX

Intestinal endocrine cells	128 NX
Colon	146 NX
Rectum	110 NX

Ito cells	102 NX
Liver	102 NX

Kupffer cells	105 NX
Liver	105 NX

Late spermatids	747 NX
Testis	747 NX

Leydig cells	135 NX
Testis	135 NX

Macrophages	144 NX
Prostate	319 NX
Pancreas	248 NX
Skin	155 NX
Kidney	152 NX
Lung	127 NX
Testis	109 NX

Melanocytes	187 NX
Skin	187 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	122 NX
Pancreas	122 NX

Mucus-secreting cells	119 NX
Colon	291 NX
Small intestine	115 NX
Rectum	109 NX

Muller glia cells	115 NX
Eye	115 NX

Pancreatic endocrine cells	188 NX
Pancreas	188 NX

Paneth cells	110 NX
Colon	187 NX
Rectum	110 NX
Small intestine	102 NX

Peritubular cells	200 NX
Testis	200 NX

Proximal tubular cells	345 NX
Kidney	345 NX

Rod photoreceptor cells	39 NX
Eye	39 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	188 NX
Pancreas	308 NX
Prostate	266 NX
Skin	179 NX
Heart muscle	161 NX

Spermatocytes	131 NX
Testis	131 NX

Spermatogonia	123 NX
Testis	123 NX

Suprabasal keratinocytes	257 NX
Skin	257 NX

Syncytiotrophoblasts	589 NX
Placenta	589 NX

T-cells	66 NX
Prostate	148 NX
Skin	108 NX
Kidney	75 NX
Colon	75 NX
Lung	66 NX
Liver	53 NX

Undifferentiated cells	113 NX
Colon	206 NX
Rectum	113 NX
Small intestine	106 NX

Urothelial cells	383 NX
Prostate	383 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.