Cell type atlas - GTF2B - The Human Protein Atlas

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GTF2B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GTF2B
Gene descriptionⁱ Full gene name according to HGNC.	General transcription factor IIB
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	30 NX
Colon	94 NX
Kidney	27 NX
Liver	23 NX

Basal glandular cells	69 NX
Prostate	69 NX

Basal keratinocytes	41 NX
Skin	41 NX

Bipolar cells	13 NX
Eye	13 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	40 NX
Lung	40 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	10 NX
Kidney	10 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	68 NX
Placenta	68 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	43 NX
Pancreas	43 NX

Early spermatids	12 NX
Testis	12 NX

Endothelial cells	27 NX
Prostate	40 NX
Pancreas	29 NX
Eye	28 NX
Liver	27 NX
Skin	23 NX
Heart muscle	23 NX
Placenta	19 NX
Testis	15 NX
Lung	12 NX

Enterocytes	28 NX
Colon	43 NX
Rectum	26 NX
Small intestine	23 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	50 NX
Placenta	50 NX

Fibroblasts	31 NX
Prostate	79 NX
Placenta	36 NX
Lung	25 NX
Skin	24 NX
Heart muscle	14 NX

Glandular cells	23 NX
Prostate	23 NX

Granulocytes	48 NX
Colon	64 NX
Lung	33 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	36 NX
Placenta	36 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	19 NX
Colon	27 NX
Rectum	12 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	39 NX
Lung	53 NX
Prostate	44 NX
Pancreas	40 NX
Skin	37 NX
Kidney	31 NX
Testis	30 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	35 NX
Pancreas	35 NX

Mucus-secreting cells	21 NX
Colon	40 NX
Small intestine	24 NX
Rectum	18 NX

Muller glia cells	24 NX
Eye	24 NX

Pancreatic endocrine cells	41 NX
Pancreas	41 NX

Paneth cells	60 NX
Colon	107 NX
Small intestine	60 NX
Rectum	23 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	42 NX
Prostate	91 NX
Skin	46 NX
Pancreas	42 NX
Heart muscle	20 NX

Spermatocytes	21 NX
Testis	21 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	126 NX
Placenta	126 NX

T-cells	55 NX
Prostate	144 NX
Colon	86 NX
Skin	58 NX
Lung	55 NX
Kidney	44 NX
Liver	29 NX

Undifferentiated cells	18 NX
Colon	23 NX
Small intestine	18 NX
Rectum	16 NX

Urothelial cells	77 NX
Prostate	77 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.