Cell type atlas - ADAM10 - The Human Protein Atlas

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ADAM10

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ADAM10
Gene descriptionⁱ Full gene name according to HGNC.	ADAM metallopeptidase domain 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes Enzymes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	77 NX
Lung	77 NX

Alveolar cells type 2	50 NX
Lung	50 NX

B-cells	31 NX
Colon	39 NX
Kidney	22 NX
Liver	20 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	24 NX
Skin	24 NX

Bipolar cells	20 NX
Eye	20 NX

Cardiomyocytes	30 NX
Heart muscle	30 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	77 NX
Kidney	77 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	27 NX
Placenta	27 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	46 NX
Pancreas	46 NX

Early spermatids	22 NX
Testis	22 NX

Endothelial cells	62 NX
Heart muscle	120 NX
Pancreas	65 NX
Placenta	62 NX
Eye	62 NX
Lung	61 NX
Prostate	52 NX
Skin	50 NX
Liver	49 NX
Testis	40 NX

Enterocytes	39 NX
Rectum	104 NX
Small intestine	41 NX
Colon	34 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	28 NX
Pancreas	28 NX

Extravillous trophoblasts	47 NX
Placenta	47 NX

Fibroblasts	29 NX
Lung	59 NX
Placenta	49 NX
Prostate	29 NX
Heart muscle	27 NX
Skin	18 NX

Glandular cells	76 NX
Prostate	76 NX

Granulocytes	28 NX
Lung	56 NX
Colon	0 NX

Hepatocytes	30 NX
Liver	30 NX

Hofbauer cells	57 NX
Placenta	57 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	35 NX
Rectum	42 NX
Colon	27 NX

Ito cells	76 NX
Liver	76 NX

Kupffer cells	87 NX
Liver	87 NX

Late spermatids	16 NX
Testis	16 NX

Leydig cells	17 NX
Testis	17 NX

Macrophages	64 NX
Lung	91 NX
Pancreas	84 NX
Kidney	76 NX
Testis	58 NX
Prostate	54 NX
Skin	23 NX

Melanocytes	44 NX
Skin	44 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	14 NX
Pancreas	14 NX

Mucus-secreting cells	46 NX
Rectum	61 NX
Small intestine	37 NX
Colon	23 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	43 NX
Rectum	52 NX
Colon	43 NX
Small intestine	35 NX

Peritubular cells	16 NX
Testis	16 NX

Proximal tubular cells	20 NX
Kidney	20 NX

Rod photoreceptor cells	33 NX
Eye	33 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	28 NX
Prostate	29 NX
Pancreas	28 NX
Heart muscle	28 NX
Skin	14 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	16 NX
Testis	16 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	22 NX
Placenta	22 NX

T-cells	44 NX
Liver	62 NX
Lung	55 NX
Prostate	44 NX
Kidney	36 NX
Colon	34 NX
Skin	23 NX

Undifferentiated cells	34 NX
Rectum	41 NX
Small intestine	30 NX
Colon	23 NX

Urothelial cells	60 NX
Prostate	60 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.