Cell type atlas - PRCP - The Human Protein Atlas

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PRCP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRCP
Gene descriptionⁱ Full gene name according to HGNC.	Prolylcarboxypeptidase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	43 NX
Liver	46 NX
Colon	46 NX
Kidney	40 NX

Basal glandular cells	36 NX
Prostate	36 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	10 NX
Eye	10 NX

Cardiomyocytes	20 NX
Heart muscle	20 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	5 NX
Lung	5 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	49 NX
Placenta	49 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	28 NX
Pancreas	28 NX

Early spermatids	24 NX
Testis	24 NX

Endothelial cells	121 NX
Placenta	417 NX
Pancreas	229 NX
Liver	216 NX
Skin	144 NX
Testis	135 NX
Prostate	118 NX
Heart muscle	85 NX
Lung	47 NX
Eye	25 NX

Enterocytes	5 NX
Rectum	13 NX
Colon	7 NX
Small intestine	4 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	11 NX
Pancreas	11 NX

Extravillous trophoblasts	99 NX
Placenta	99 NX

Fibroblasts	50 NX
Skin	64 NX
Prostate	55 NX
Placenta	50 NX
Heart muscle	25 NX
Lung	22 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	13 NX
Colon	18 NX
Lung	7 NX

Hepatocytes	57 NX
Liver	57 NX

Hofbauer cells	73 NX
Placenta	73 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	19 NX
Colon	24 NX
Rectum	14 NX

Ito cells	393 NX
Liver	393 NX

Kupffer cells	149 NX
Liver	149 NX

Late spermatids	39 NX
Testis	39 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	76 NX
Skin	105 NX
Kidney	93 NX
Testis	81 NX
Prostate	72 NX
Pancreas	63 NX
Lung	29 NX

Melanocytes	67 NX
Skin	67 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	54 NX
Pancreas	54 NX

Mucus-secreting cells	19 NX
Rectum	23 NX
Small intestine	19 NX
Colon	10 NX

Muller glia cells	57 NX
Eye	57 NX

Pancreatic endocrine cells	10 NX
Pancreas	10 NX

Paneth cells	7 NX
Rectum	21 NX
Small intestine	7 NX
Colon	0 NX

Peritubular cells	44 NX
Testis	44 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	27 NX
Pancreas	35 NX
Prostate	31 NX
Skin	26 NX
Heart muscle	12 NX

Spermatocytes	24 NX
Testis	24 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	25 NX
Skin	32 NX
Liver	28 NX
Colon	27 NX
Kidney	22 NX
Prostate	13 NX
Lung	13 NX

Undifferentiated cells	20 NX
Rectum	25 NX
Small intestine	18 NX
Colon	10 NX

Urothelial cells	34 NX
Prostate	34 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.