Cell type atlas - TPMT - The Human Protein Atlas

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TPMT

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPMT
Gene descriptionⁱ Full gene name according to HGNC.	Thiopurine S-methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	18 NX
Kidney	40 NX
Colon	15 NX
Liver	11 NX

Basal glandular cells	32 NX
Prostate	32 NX

Basal keratinocytes	38 NX
Skin	38 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	4 NX
Lung	4 NX

Club cells	7 NX
Lung	7 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	17 NX
Placenta	17 NX

Distal tubular cells	98 NX
Kidney	98 NX

Ductal cells	34 NX
Pancreas	34 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	12 NX
Placenta	19 NX
Skin	17 NX
Pancreas	14 NX
Testis	13 NX
Lung	12 NX
Heart muscle	12 NX
Prostate	12 NX
Eye	11 NX
Liver	7 NX

Enterocytes	80 NX
Colon	159 NX
Rectum	113 NX
Small intestine	71 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	33 NX
Pancreas	33 NX

Extravillous trophoblasts	22 NX
Placenta	22 NX

Fibroblasts	12 NX
Skin	17 NX
Heart muscle	16 NX
Prostate	12 NX
Placenta	9 NX
Lung	7 NX

Glandular cells	34 NX
Prostate	34 NX

Granulocytes	23 NX
Colon	37 NX
Lung	9 NX

Hepatocytes	80 NX
Liver	80 NX

Hofbauer cells	41 NX
Placenta	41 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	23 NX
Rectum	26 NX
Colon	20 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	2 NX
Testis	1 NX

Leydig cells	4 NX
Testis	4 NX

Macrophages	57 NX
Pancreas	77 NX
Kidney	62 NX
Skin	60 NX
Prostate	60 NX
Lung	33 NX
Testis	27 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	20 NX
Pancreas	20 NX

Mucus-secreting cells	32 NX
Rectum	35 NX
Colon	33 NX
Small intestine	26 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	51 NX
Pancreas	51 NX

Paneth cells	79 NX
Colon	138 NX
Rectum	79 NX
Small intestine	70 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	230 NX
Kidney	230 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	15 NX
Pancreas	38 NX
Prostate	15 NX
Heart muscle	15 NX
Skin	14 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	30 NX
Skin	30 NX

Syncytiotrophoblasts	15 NX
Placenta	15 NX

T-cells	24 NX
Kidney	42 NX
Colon	32 NX
Prostate	31 NX
Liver	22 NX
Lung	20 NX
Skin	19 NX

Undifferentiated cells	37 NX
Colon	56 NX
Rectum	37 NX
Small intestine	34 NX

Urothelial cells	71 NX
Prostate	71 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.