Cell type atlas - HINT2 - The Human Protein Atlas

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HINT2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HINT2
Gene descriptionⁱ Full gene name according to HGNC.	Histidine triad nucleotide binding protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells, Proximal tubular cells, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Proximal tubular cells, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	11 NX
Lung	11 NX

B-cells	63 NX
Kidney	98 NX
Liver	71 NX
Colon	25 NX

Basal glandular cells	61 NX
Prostate	61 NX

Basal keratinocytes	40 NX
Skin	40 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	96 NX
Heart muscle	96 NX

Cholangiocytes	125 NX
Liver	125 NX

Ciliated cells	54 NX
Lung	54 NX

Club cells	14 NX
Lung	14 NX

Collecting duct cells	77 NX
Kidney	77 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	143 NX
Placenta	143 NX

Distal tubular cells	537 NX
Kidney	537 NX

Ductal cells	102 NX
Pancreas	102 NX

Early spermatids	54 NX
Testis	54 NX

Endothelial cells	50 NX
Placenta	96 NX
Liver	67 NX
Heart muscle	64 NX
Skin	54 NX
Testis	53 NX
Eye	44 NX
Pancreas	43 NX
Prostate	25 NX
Lung	3 NX

Enterocytes	143 NX
Small intestine	150 NX
Colon	143 NX
Rectum	110 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	150 NX
Pancreas	150 NX

Extravillous trophoblasts	55 NX
Placenta	55 NX

Fibroblasts	58 NX
Heart muscle	88 NX
Placenta	64 NX
Skin	59 NX
Prostate	22 NX
Lung	11 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	18 NX
Colon	28 NX
Lung	9 NX

Hepatocytes	366 NX
Liver	366 NX

Hofbauer cells	96 NX
Placenta	96 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	92 NX
Rectum	103 NX
Colon	82 NX

Ito cells	63 NX
Liver	63 NX

Kupffer cells	58 NX
Liver	58 NX

Late spermatids	112 NX
Testis	111 NX

Leydig cells	37 NX
Testis	37 NX

Macrophages	48 NX
Kidney	94 NX
Pancreas	84 NX
Prostate	51 NX
Skin	51 NX
Testis	39 NX
Lung	13 NX

Melanocytes	115 NX
Skin	115 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	71 NX
Pancreas	71 NX

Mucus-secreting cells	107 NX
Colon	132 NX
Small intestine	107 NX
Rectum	102 NX

Muller glia cells	69 NX
Eye	69 NX

Pancreatic endocrine cells	83 NX
Pancreas	83 NX

Paneth cells	158 NX
Small intestine	179 NX
Colon	158 NX
Rectum	90 NX

Peritubular cells	42 NX
Testis	42 NX

Proximal tubular cells	464 NX
Kidney	464 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	72 NX
Heart muscle	103 NX
Pancreas	72 NX
Skin	63 NX
Prostate	36 NX

Spermatocytes	32 NX
Testis	32 NX

Spermatogonia	82 NX
Testis	82 NX

Suprabasal keratinocytes	40 NX
Skin	40 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	67 NX
Kidney	96 NX
Liver	90 NX
Skin	49 NX
Prostate	48 NX
Colon	48 NX
Lung	19 NX

Undifferentiated cells	121 NX
Rectum	125 NX
Small intestine	117 NX
Colon	111 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.