Cell type atlas - FAM129B - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FAM129B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM129B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 129 member B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, myeloid DC, intermediate monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	0 NX
Kidney	0 NX
Liver	0 NX
Colon	0 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	29 NX
Skin	29 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	4 NX
Heart muscle	4 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	59 NX
Placenta	59 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	73 NX
Pancreas	72 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	29 NX
Pancreas	61 NX
Testis	61 NX
Prostate	55 NX
Placenta	41 NX
Eye	29 NX
Skin	25 NX
Heart muscle	13 NX
Lung	9 NX
Liver	9 NX

Enterocytes	94 NX
Colon	132 NX
Rectum	95 NX
Small intestine	59 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	93 NX
Pancreas	93 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	20 NX
Placenta	24 NX
Prostate	22 NX
Skin	16 NX
Heart muscle	11 NX
Lung	8 NX

Glandular cells	57 NX
Prostate	57 NX

Granulocytes	29 NX
Lung	30 NX
Colon	28 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	22 NX
Placenta	21 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	21 NX
Rectum	26 NX
Colon	17 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	12 NX
Liver	12 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	23 NX
Skin	38 NX
Pancreas	26 NX
Testis	21 NX
Lung	19 NX
Kidney	12 NX
Prostate	11 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3 NX
Pancreas	3 NX

Mucus-secreting cells	42 NX
Rectum	47 NX
Colon	43 NX
Small intestine	24 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	107 NX
Pancreas	107 NX

Paneth cells	42 NX
Colon	43 NX
Rectum	42 NX
Small intestine	21 NX

Peritubular cells	47 NX
Testis	47 NX

Proximal tubular cells	2 NX
Kidney	2 NX

Rod photoreceptor cells	2 NX
Eye	1 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	32 NX
Pancreas	73 NX
Prostate	32 NX
Skin	26 NX
Heart muscle	2 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	33 NX
Skin	33 NX

Syncytiotrophoblasts	101 NX
Placenta	101 NX

T-cells	2 NX
Lung	10 NX
Skin	8 NX
Colon	7 NX
Liver	1 NX
Kidney	1 NX
Prostate	0 NX

Undifferentiated cells	37 NX
Colon	88 NX
Rectum	51 NX
Small intestine	27 NX

Urothelial cells	105 NX
Prostate	105 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.