Cell type atlas - YME1L1 - The Human Protein Atlas

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YME1L1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YME1L1
Gene descriptionⁱ Full gene name according to HGNC.	YME1 like 1 ATPase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	67 NX
Lung	67 NX

B-cells	93 NX
Colon	97 NX
Liver	92 NX
Kidney	89 NX

Basal glandular cells	71 NX
Prostate	71 NX

Basal keratinocytes	62 NX
Skin	62 NX

Bipolar cells	52 NX
Eye	52 NX

Cardiomyocytes	93 NX
Heart muscle	93 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	80 NX
Lung	80 NX

Club cells	71 NX
Lung	71 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	79 NX
Eye	79 NX

Cytotrophoblasts	54 NX
Placenta	54 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	46 NX
Pancreas	46 NX

Early spermatids	38 NX
Testis	38 NX

Endothelial cells	62 NX
Prostate	105 NX
Eye	102 NX
Lung	90 NX
Placenta	62 NX
Skin	60 NX
Testis	59 NX
Heart muscle	59 NX
Pancreas	54 NX
Liver	47 NX

Enterocytes	166 NX
Colon	201 NX
Small intestine	135 NX
Rectum	89 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	60 NX
Placenta	60 NX

Fibroblasts	63 NX
Prostate	179 NX
Lung	103 NX
Heart muscle	75 NX
Skin	64 NX
Placenta	56 NX

Glandular cells	67 NX
Prostate	67 NX

Granulocytes	108 NX
Lung	114 NX
Colon	101 NX

Hepatocytes	65 NX
Liver	65 NX

Hofbauer cells	65 NX
Placenta	64 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	48 NX
Colon	54 NX
Rectum	42 NX

Ito cells	55 NX
Liver	55 NX

Kupffer cells	92 NX
Liver	92 NX

Late spermatids	21 NX
Testis	21 NX

Leydig cells	54 NX
Testis	54 NX

Macrophages	112 NX
Testis	127 NX
Lung	125 NX
Skin	113 NX
Prostate	85 NX
Kidney	63 NX
Pancreas	30 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	43 NX
Pancreas	43 NX

Mucus-secreting cells	68 NX
Colon	184 NX
Small intestine	66 NX
Rectum	64 NX

Muller glia cells	59 NX
Eye	59 NX

Pancreatic endocrine cells	54 NX
Pancreas	54 NX

Paneth cells	84 NX
Colon	144 NX
Small intestine	84 NX
Rectum	66 NX

Peritubular cells	41 NX
Testis	41 NX

Proximal tubular cells	38 NX
Kidney	38 NX

Rod photoreceptor cells	68 NX
Eye	68 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	76 NX
Heart muscle	103 NX
Skin	102 NX
Prostate	76 NX
Pancreas	41 NX

Spermatocytes	84 NX
Testis	84 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	57 NX
Skin	57 NX

Syncytiotrophoblasts	79 NX
Placenta	79 NX

T-cells	85 NX
Colon	112 NX
Lung	101 NX
Liver	96 NX
Prostate	74 NX
Skin	73 NX
Kidney	60 NX

Undifferentiated cells	70 NX
Colon	128 NX
Small intestine	80 NX
Rectum	57 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.