Cell type atlas - MARCH7 - The Human Protein Atlas

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MARCH7

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MARCH7
Gene descriptionⁱ Full gene name according to HGNC.	Membrane associated ring-CH-type finger 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	69 NX
Lung	69 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	54 NX
Kidney	89 NX
Liver	49 NX
Colon	37 NX

Basal glandular cells	0 NX
Prostate	0 NX

Basal keratinocytes	76 NX
Skin	76 NX

Bipolar cells	37 NX
Eye	37 NX

Cardiomyocytes	79 NX
Heart muscle	79 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	44 NX
Lung	44 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	0 NX
Pancreas	0 NX

Early spermatids	208 NX
Testis	208 NX

Endothelial cells	38 NX
Heart muscle	90 NX
Lung	79 NX
Skin	44 NX
Testis	43 NX
Eye	38 NX
Liver	32 NX
Placenta	30 NX
Pancreas	0 NX
Prostate	0 NX

Enterocytes	18 NX
Rectum	24 NX
Colon	17 NX
Small intestine	17 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	0 NX
Pancreas	0 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	37 NX
Lung	81 NX
Heart muscle	57 NX
Skin	38 NX
Placenta	33 NX
Prostate	0 NX

Glandular cells	0 NX
Prostate	0 NX

Granulocytes	53 NX
Lung	79 NX
Colon	28 NX

Hepatocytes	28 NX
Liver	28 NX

Hofbauer cells	29 NX
Placenta	29 NX

Horizontal cells	46 NX
Eye	46 NX

Intestinal endocrine cells	28 NX
Rectum	28 NX
Colon	27 NX

Ito cells	52 NX
Liver	52 NX

Kupffer cells	38 NX
Liver	38 NX

Late spermatids	46 NX
Testis	46 NX

Leydig cells	46 NX
Testis	46 NX

Macrophages	42 NX
Testis	63 NX
Lung	52 NX
Kidney	40 NX
Skin	32 NX
Pancreas	0 NX
Prostate	0 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	25 NX
Rectum	27 NX
Small intestine	21 NX
Colon	20 NX

Muller glia cells	39 NX
Eye	39 NX

Pancreatic endocrine cells	0 NX
Pancreas	0 NX

Paneth cells	18 NX
Rectum	25 NX
Small intestine	18 NX
Colon	12 NX

Peritubular cells	39 NX
Testis	39 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	45 NX
Heart muscle	76 NX
Skin	46 NX
Prostate	0 NX
Pancreas	0 NX

Spermatocytes	77 NX
Testis	77 NX

Spermatogonia	32 NX
Testis	32 NX

Suprabasal keratinocytes	79 NX
Skin	79 NX

Syncytiotrophoblasts	37 NX
Placenta	37 NX

T-cells	42 NX
Lung	69 NX
Colon	62 NX
Liver	48 NX
Kidney	36 NX
Skin	36 NX
Prostate	0 NX

Undifferentiated cells	22 NX
Colon	27 NX
Rectum	25 NX
Small intestine	18 NX

Urothelial cells	0 NX
Prostate	0 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.