Cell type atlas - DNAJB2 - The Human Protein Atlas

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DNAJB2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNAJB2
Gene descriptionⁱ Full gene name according to HGNC.	DnaJ heat shock protein family (Hsp40) member B2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	33 NX
Lung	33 NX

B-cells	23 NX
Colon	64 NX
Kidney	27 NX
Liver	16 NX

Basal glandular cells	40 NX
Prostate	40 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	97 NX
Eye	97 NX

Cardiomyocytes	55 NX
Heart muscle	55 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	17 NX
Lung	17 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	53 NX
Eye	53 NX

Cytotrophoblasts	32 NX
Placenta	32 NX

Distal tubular cells	66 NX
Kidney	66 NX

Ductal cells	51 NX
Pancreas	51 NX

Early spermatids	35 NX
Testis	34 NX

Endothelial cells	20 NX
Heart muscle	39 NX
Eye	35 NX
Placenta	25 NX
Skin	20 NX
Testis	20 NX
Prostate	19 NX
Lung	12 NX
Pancreas	11 NX
Liver	11 NX

Enterocytes	30 NX
Colon	42 NX
Rectum	38 NX
Small intestine	27 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	29 NX
Pancreas	29 NX

Extravillous trophoblasts	28 NX
Placenta	28 NX

Fibroblasts	28 NX
Heart muscle	47 NX
Prostate	38 NX
Skin	28 NX
Placenta	23 NX
Lung	5 NX

Glandular cells	53 NX
Prostate	53 NX

Granulocytes	25 NX
Colon	46 NX
Lung	5 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	25 NX
Placenta	25 NX

Horizontal cells	76 NX
Eye	76 NX

Intestinal endocrine cells	52 NX
Colon	68 NX
Rectum	35 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	16 NX
Liver	16 NX

Late spermatids	54 NX
Testis	54 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	18 NX
Prostate	52 NX
Skin	22 NX
Pancreas	19 NX
Testis	17 NX
Kidney	15 NX
Lung	13 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	38 NX
Colon	57 NX
Small intestine	37 NX
Rectum	32 NX

Muller glia cells	72 NX
Eye	72 NX

Pancreatic endocrine cells	54 NX
Pancreas	54 NX

Paneth cells	23 NX
Rectum	27 NX
Colon	23 NX
Small intestine	14 NX

Peritubular cells	37 NX
Testis	37 NX

Proximal tubular cells	38 NX
Kidney	38 NX

Rod photoreceptor cells	80 NX
Eye	80 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	27 NX
Prostate	54 NX
Heart muscle	48 NX
Skin	25 NX
Pancreas	18 NX

Spermatocytes	45 NX
Testis	45 NX

Spermatogonia	19 NX
Testis	19 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	58 NX
Placenta	58 NX

T-cells	27 NX
Prostate	57 NX
Colon	54 NX
Skin	33 NX
Kidney	28 NX
Liver	22 NX
Lung	9 NX

Undifferentiated cells	18 NX
Colon	31 NX
Rectum	18 NX
Small intestine	13 NX

Urothelial cells	19 NX
Prostate	19 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.