Cell type atlas - GNS - The Human Protein Atlas

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GNS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GNS
Gene descriptionⁱ Full gene name according to HGNC.	Glucosamine (N-acetyl)-6-sulfatase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	17 NX
Colon	19 NX
Liver	19 NX
Kidney	5 NX

Basal glandular cells	7 NX
Prostate	7 NX

Basal keratinocytes	15 NX
Skin	15 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	57 NX
Heart muscle	57 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	21 NX
Lung	21 NX

Club cells	18 NX
Lung	18 NX

Collecting duct cells	98 NX
Kidney	98 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	16 NX
Placenta	16 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	24 NX
Testis	24 NX

Endothelial cells	39 NX
Placenta	53 NX
Liver	49 NX
Skin	46 NX
Lung	44 NX
Prostate	40 NX
Heart muscle	37 NX
Testis	35 NX
Eye	34 NX
Pancreas	14 NX

Enterocytes	31 NX
Small intestine	53 NX
Rectum	34 NX
Colon	12 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	13 NX
Pancreas	13 NX

Extravillous trophoblasts	15 NX
Placenta	15 NX

Fibroblasts	23 NX
Heart muscle	52 NX
Skin	31 NX
Lung	27 NX
Prostate	19 NX
Placenta	18 NX

Glandular cells	23 NX
Prostate	23 NX

Granulocytes	46 NX
Lung	56 NX
Colon	37 NX

Hepatocytes	54 NX
Liver	54 NX

Hofbauer cells	73 NX
Placenta	73 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	40 NX
Colon	41 NX
Rectum	40 NX

Ito cells	69 NX
Liver	69 NX

Kupffer cells	167 NX
Liver	167 NX

Late spermatids	20 NX
Testis	19 NX

Leydig cells	32 NX
Testis	32 NX

Macrophages	66 NX
Lung	84 NX
Kidney	83 NX
Prostate	81 NX
Testis	69 NX
Pancreas	61 NX
Skin	36 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	24 NX
Pancreas	24 NX

Mucus-secreting cells	19 NX
Rectum	20 NX
Small intestine	16 NX
Colon	8 NX

Muller glia cells	24 NX
Eye	24 NX

Pancreatic endocrine cells	22 NX
Pancreas	21 NX

Paneth cells	16 NX
Small intestine	21 NX
Rectum	16 NX
Colon	6 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	62 NX
Kidney	62 NX

Rod photoreceptor cells	6 NX
Eye	6 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	19 NX
Heart muscle	43 NX
Skin	21 NX
Pancreas	17 NX
Prostate	16 NX

Spermatocytes	11 NX
Testis	11 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	11 NX
Skin	11 NX

Syncytiotrophoblasts	24 NX
Placenta	24 NX

T-cells	10 NX
Lung	23 NX
Liver	14 NX
Kidney	12 NX
Colon	10 NX
Prostate	9 NX
Skin	9 NX

Undifferentiated cells	16 NX
Rectum	22 NX
Small intestine	14 NX
Colon	8 NX

Urothelial cells	16 NX
Prostate	16 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.