Cell type atlas - USP15 - The Human Protein Atlas

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USP15

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP15
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 15
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	91 NX
Colon	136 NX
Kidney	98 NX
Liver	62 NX

Basal glandular cells	32 NX
Prostate	32 NX

Basal keratinocytes	52 NX
Skin	52 NX

Bipolar cells	55 NX
Eye	55 NX

Cardiomyocytes	63 NX
Heart muscle	63 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	43 NX
Lung	43 NX

Club cells	59 NX
Lung	59 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	104 NX
Eye	104 NX

Cytotrophoblasts	25 NX
Placenta	25 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	140 NX
Testis	140 NX

Endothelial cells	45 NX
Heart muscle	75 NX
Pancreas	54 NX
Eye	49 NX
Prostate	45 NX
Skin	45 NX
Liver	34 NX
Testis	31 NX
Placenta	25 NX
Lung	23 NX

Enterocytes	32 NX
Colon	55 NX
Rectum	32 NX
Small intestine	27 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	36 NX
Pancreas	36 NX

Extravillous trophoblasts	36 NX
Placenta	36 NX

Fibroblasts	50 NX
Heart muscle	122 NX
Lung	60 NX
Prostate	52 NX
Skin	50 NX
Placenta	22 NX

Glandular cells	32 NX
Prostate	32 NX

Granulocytes	86 NX
Lung	98 NX
Colon	74 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	41 NX
Placenta	41 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	40 NX
Rectum	47 NX
Colon	34 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	108 NX
Liver	108 NX

Late spermatids	131 NX
Testis	131 NX

Leydig cells	57 NX
Testis	57 NX

Macrophages	95 NX
Lung	174 NX
Testis	150 NX
Skin	93 NX
Kidney	90 NX
Pancreas	77 NX
Prostate	52 NX

Melanocytes	51 NX
Skin	51 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	36 NX
Pancreas	36 NX

Mucus-secreting cells	23 NX
Colon	44 NX
Small intestine	27 NX
Rectum	21 NX

Muller glia cells	24 NX
Eye	24 NX

Pancreatic endocrine cells	41 NX
Pancreas	41 NX

Paneth cells	46 NX
Colon	58 NX
Small intestine	46 NX
Rectum	25 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	146 NX
Eye	146 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	57 NX
Heart muscle	78 NX
Skin	58 NX
Prostate	57 NX
Pancreas	23 NX

Spermatocytes	63 NX
Testis	63 NX

Spermatogonia	42 NX
Testis	42 NX

Suprabasal keratinocytes	67 NX
Skin	67 NX

Syncytiotrophoblasts	55 NX
Placenta	55 NX

T-cells	65 NX
Lung	131 NX
Colon	125 NX
Skin	116 NX
Kidney	65 NX
Prostate	61 NX
Liver	56 NX

Undifferentiated cells	23 NX
Colon	34 NX
Rectum	24 NX
Small intestine	18 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.