Cell type atlas - OS9 - The Human Protein Atlas

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OS9

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	OS9
Gene descriptionⁱ Full gene name according to HGNC.	OS9, endoplasmic reticulum lectin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (RH-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	110 NX
Lung	110 NX

B-cells	55 NX
Liver	84 NX
Kidney	62 NX
Colon	48 NX

Basal glandular cells	75 NX
Prostate	75 NX

Basal keratinocytes	51 NX
Skin	51 NX

Bipolar cells	43 NX
Eye	43 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	92 NX
Liver	92 NX

Ciliated cells	94 NX
Lung	94 NX

Club cells	104 NX
Lung	104 NX

Collecting duct cells	70 NX
Kidney	70 NX

Cone photoreceptor cells	73 NX
Eye	73 NX

Cytotrophoblasts	122 NX
Placenta	122 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	115 NX
Pancreas	115 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	77 NX
Lung	163 NX
Pancreas	125 NX
Placenta	103 NX
Testis	96 NX
Liver	85 NX
Eye	76 NX
Skin	74 NX
Prostate	50 NX
Heart muscle	17 NX

Enterocytes	143 NX
Colon	189 NX
Small intestine	137 NX
Rectum	118 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	96 NX
Pancreas	96 NX

Extravillous trophoblasts	107 NX
Placenta	107 NX

Fibroblasts	100 NX
Placenta	119 NX
Skin	114 NX
Lung	96 NX
Prostate	72 NX
Heart muscle	30 NX

Glandular cells	65 NX
Prostate	65 NX

Granulocytes	87 NX
Lung	119 NX
Colon	55 NX

Hepatocytes	139 NX
Liver	139 NX

Hofbauer cells	129 NX
Placenta	129 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	100 NX
Colon	105 NX
Rectum	94 NX

Ito cells	77 NX
Liver	77 NX

Kupffer cells	105 NX
Liver	105 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	105 NX
Testis	105 NX

Macrophages	115 NX
Lung	173 NX
Pancreas	150 NX
Testis	136 NX
Kidney	95 NX
Prostate	91 NX
Skin	89 NX

Melanocytes	113 NX
Skin	113 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	159 NX
Pancreas	159 NX

Mucus-secreting cells	107 NX
Colon	231 NX
Rectum	110 NX
Small intestine	101 NX

Muller glia cells	86 NX
Eye	86 NX

Pancreatic endocrine cells	85 NX
Pancreas	85 NX

Paneth cells	130 NX
Colon	179 NX
Small intestine	130 NX
Rectum	112 NX

Peritubular cells	74 NX
Testis	74 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	91 NX
Testis	91 NX

Smooth muscle cells	58 NX
Pancreas	117 NX
Prostate	69 NX
Skin	53 NX
Heart muscle	17 NX

Spermatocytes	33 NX
Testis	33 NX

Spermatogonia	55 NX
Testis	55 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	165 NX
Placenta	165 NX

T-cells	69 NX
Lung	118 NX
Kidney	77 NX
Prostate	70 NX
Liver	60 NX
Colon	54 NX
Skin	54 NX

Undifferentiated cells	79 NX
Colon	102 NX
Rectum	89 NX
Small intestine	76 NX

Urothelial cells	57 NX
Prostate	57 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.